Mitoses and cancer

Medical Hypotheses
Anna Batistatou

Abstract

Mitoses are coupled to cell proliferation. In non-neoplastic cells they are usually symmetric and typical and lead to increase in cell number. Cancer cells are notorious for their asymmetric divisions, which are considered to reflect abnormalities due to disordered growth. The centrosome controls the mitotic activity and it has been proposed that centrosomal defects possibly contribute to carcinogenesis and aneuploidy of cancer cells. So far the atypical mitoses often seen in neoplastic cells are not considered unique. However careful observation of atypical mitoses in various neoplasms revealed that although they were indeed "atypical" they resembled each other within the same tumor and were different from those of other tumors. It is proposed that specific centrosomal alterations, which lead to a limited variety of atypical mitotic figures in each neoplasm, are not a random result but a distinct event that is possibly involved in carcinogenesis.

References

Feb 1, 1997·Current Opinion in Cell Biology·J C Waters, E Salmon
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·W S SaundersS M Gollin
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·Y MiyoshiS Noguchi
Jun 18, 2002·FEBS Letters·P Meraldi, E A Nigg
Jul 10, 2003·Cancer Genetics and Cytogenetics·K Al-RomaihJ A Squire

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Citations

Dec 15, 2006·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Godwin N Isitor, Ramona Thorne
Jul 19, 2005·Medical Hypotheses·Anna Batistatou, Konstantinos A Charalabopoulos
May 5, 2007·International Journal of Surgical Pathology·Anna Batistatou, Konstantinos A Charalabopoulos
Sep 9, 2006·International Journal of Surgical Pathology·Chrisoula D Scopa, Helen P Kourea
Mar 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shimaa A AbassMamdouh Mohammad El-Shishtawy

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