PMID: 9552424Jan 1, 1997Paper

Mitosis and checkpoints that control progression through mitosis in vertebrate somatic cells

Progress in Cell Cycle Research
Conly L Rieder, Alexey Khodjakov

Abstract

During mitosis in vertebrates the sister kinetochores on each replicated chromosome interact with two separating arrays of astral microtubules to form a bipolar spindle that produces and/or directs the forces for chromosome motion. In order to ensure faithful chromosome segregation cells have evolved mechanisms that delay progress into and out of mitosis until certain events are completed. At least two of these mitotic "checkpoint controls" can be identified in vertebrates. The first prevents nuclear envelope breakdown, and thus spindle formation, when the integrity of some nuclear component(s) is compromised. The second prevents chromosome disjunction and exit from mitosis until all of the kinetochores are attached to the spindle.

Citations

Jan 9, 2001·Nature Cell Biology·J Pines, C L Rieder
Nov 18, 2003·Annual Review of Genetics·Daniel J Lew, Daniel J Burke
Sep 23, 2000·Anti-cancer Drugs·V SandorD L Sackett
Aug 21, 2002·Journal of Cell Science·Jun ZhouHarish C Joshi
Mar 7, 2002·Developmental Cell·Michael D BlowerGary H Karpen

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