PMID: 3770731Nov 1, 1986Paper

Mitosis counts: reproducibility and significance in grading of malignancy

Human Pathology
K Donhuijsen

Abstract

The interindividual and intraindividual reproducibility of mitosis counts was investigated in 10 cases of malignant non-Hodgkin's lymphoma. With thickness of histologic sections, staining, and the area measured kept constant, the degree of reproducibility was found to be dependent largely on the experience of the investigator. For investigators at similar levels of experience, the mitosis rates obtained were of the same order of magnitude. However, defined mitosis counts do not allow unrestricted grading of malignancy, even after elimination of methodologic pitfalls. Proliferation rates of malignant tumors cannot be expected to be constant due to biologic conditions, such as varying metabolic activity or tumor cell heterogeneity.

Citations

May 20, 1999·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·G SarliP S Marcato
Nov 11, 2009·Acta Ophthalmologica·Martina AngiSarah E Coupland
Aug 1, 1988·Diseases of the Colon and Rectum·M Bak, P Asschenfeldt
Sep 1, 1996·Histopathology·M D JeffersE M Macaulay
Jul 14, 1999·Seminars in Surgical Oncology·S Singer
Mar 24, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B S PhillipsB R Madewell
Jun 20, 2002·Journal of Neuropathology and Experimental Neurology·Richard A Prayson
Mar 28, 2006·Journal of Cellular and Molecular Medicine·Lea Rath-WolfsonRumelia Koren
Sep 1, 1994·Seminars in Surgical Oncology·W J Frable
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·R D StartJ H Smith
Jun 22, 2000·The Journal of Pathology·E van der HarstR R de Krijger
Dec 1, 1990·Histopathology·D C Brown, K C Gatter
Oct 20, 1998·The Laryngoscope·A KropveldG J Hordijk
Jan 18, 2014·American Journal of Clinical Pathology·Robin T Vollmer
Nov 18, 2020·Cancers·Andrea Daniela MaierTiit Mathiesen
Aug 25, 2012·The Journal of Contemporary Dental Practice·K Shailaja YadavSanjay Reddy Bommu
Nov 1, 1995·Critical Reviews in Oncology/hematology·R P VethM Pruszczynski
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D L SchipperD J Wagener
Jul 1, 1990·Human Pathology·K DonhuijsenV Budach

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