Mitosis, diffusible crosslinkers, and the ideal gas law

Cell
David J Odde

Abstract

During mitosis, molecular motors hydrolyze ATP to generate sliding forces between adjacent microtubules and form the bipolar mitotic spindle. Lansky et al. now show that the diffusible microtubule crosslinker Ase1p can generate sliding forces between adjacent microtubules, and it does so without ATP hydrolysis.

References

Sep 9, 1994·Science·C BustamanteS Smith
Aug 16, 2013·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Joshua PringleJennifer L Ross

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Citations

Aug 10, 2016·Current Biology : CB·Thomas H CheffingsMohan K Balasubramanian
Dec 13, 2016·Biology·Jonathan M ScholeyIngrid Brust-Mascher
Jun 17, 2020·Journal of Cell Science·Marcus BraunZdenek Lansky
Jul 30, 2021·Nature Communications·Ondřej KučeraZdenek Lansky

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