Mitosis: don't get mad, get even

Current Biology : CB
M Glotzer

Abstract

The 'mitotic spindle checkpoint' ensures that, before a cell exits from mitosis, all of its chromosomes are aligned on the spindle to form the metaphase plate. Mad2 is an essential component of this checkpoint system and it binds specifically to unattached kinetochores.

References

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Citations

May 5, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li WangDaiming Fan
May 23, 2006·Biochemical and Biophysical Research Communications·Yulei DuDaiming Fan
Sep 14, 2013·Human Molecular Genetics·Hyang Mi MoonAnthony Wynshaw-Boris
Aug 31, 2000·Annual Review of Biochemistry·D A Compton
Sep 27, 2018·Scientific Reports·M S RashidW R Taylor

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Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

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