Mitosis: short-circuiting spindle checkpoint signaling

Current Biology : CB
Xuelian Luo, Hongtao Yu

Abstract

The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

References

Mar 17, 2004·Oncogene·Rajnish Bharadwaj, Hongtao Yu
Mar 21, 2007·Genes & Development·Janet L Burton, Mark J Solomon
Apr 12, 2007·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Edward D Salmon
Oct 9, 2007·Current Opinion in Structural Biology·Marina Mapelli, Andrea Musacchio
Nov 13, 2008·Structure·Xuelian Luo, Hongtao Yu
Feb 22, 2011·Nature Cell Biology·Daisuke Izawa, Jonathon Pines
Jan 3, 2012·Current Biology : CB·Derek T C Lau, Andrew W Murray

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