Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Ling YuJia-Lu Chen

Abstract

Osteosarcoma is the most common primary malignancy of bone. Overexpression of mitotic arrest defective protein 2 (MAD2) is found in many human neoplasms, but its role in the oncogenesis of osteosarcoma is an untouched topic. The objective of this research was to observe the expression of MAD2 in human osteosarcoma and explore its clinicopathologic significance. MAD2 expression was analyzed in 48 primary osteosarcoma cases (19 osteoblastic osteosarcomas, 17 chondroblastic osteosarcomas and 12 fibroblastic osteosarcomas) using immunohistochemistry. A total of 20 normal bone specimens formed a control group. MAD2 was commonly overexpressed in human osteosarcoma. Immunopositivity was higher in tumors with lower differentiation and higher clinical stage. Increased expression of MAD2 was associated with earlier metastasis and poorer survival. Our findings provide evidence that MAD2 contributes to the pathogenesis and development of human osteosarcoma, Testing may have a clinical role in predicting prognosis, selecting appropriate chemotherapeutic strategies and providing novel strategies for osteosarcoma therapy.

References

Feb 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M DavisP J Goodwin
May 1, 1997·Cancer Genetics and Cytogenetics·J A BridgeJ R Neff
Jan 1, 1999·Nature·C LengauerB Vogelstein
Nov 7, 2000·Genes, Chromosomes & Cancer·M J PercyE M Petty
Jun 16, 2001·International Journal of Cancer. Journal International Du Cancer·E HernandoC Cordon-Cardo
Sep 27, 2001·Japanese Journal of Cancer Research : Gann·K TanakaT Nobori
Mar 17, 2004·Oncogene·Rajnish Bharadwaj, Hongtao Yu
Apr 3, 2004·Cancer Research·Tamotsu SudoNaoto T Ueno
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Geert J P L KopsDon W Cleveland
Oct 4, 2005·The Cancer Journal·Lisa L Wang
Dec 8, 2005·Neoplasia : an International Journal for Oncology Research·C Parker GibbsDennis A Steindler
May 23, 2006·Biochemical and Biophysical Research Communications·Yulei DuDaiming Fan
Oct 18, 2006·International Journal of Cancer. Journal International Du Cancer·Caroline RimkusKlaus-Peter Janssen
Dec 27, 2006·Cancer Cell·Rocío SotilloRobert Benezra
Feb 1, 2007·DNA and Cell Biology·Maya Kansara, David M Thomas
Apr 22, 2008·Mutation Research·D A RuddyJ E Monahan

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Citations

Jan 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yang BianKatsumi Kitagawa
Aug 2, 2014·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Younghye KimYoung-Sik Kim
Sep 9, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Ling YuJianhua Liu
Jun 23, 2015·Molecular Medicine Reports·Lu SunBing Yan
Mar 8, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tatsuya KatoMitsuhito Kaji
Oct 12, 2010·Mutation Research·Alejandro López-Saavedra, Luis A Herrera
Jun 4, 2013·Biomaterials·Pauline ResnierCatherine Passirani
Jun 11, 2011·Current Biology : CB·John R DaumGary J Gorbsky
May 18, 2011·Biochemical and Biophysical Research Communications·Jennifer A Keller, Elizabeth M Petty
Jul 8, 2018·International Journal of Cancer. Journal International Du Cancer·Giorgia SimonettiGiovanni Martinelli
Apr 26, 2017·Frontiers in Pharmacology·Francesco R EvolaGiuseppe Sessa
Jun 29, 2012·Oncology Letters·Yusuke NakanoOsamu Ishiko

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