Mitotic chromosome condensation

Annual Review of Cell and Developmental Biology
D Koshland, A V Strunnikov

Abstract

In this chapter, we review the structure and composition of interphase and mitotic chromosomes. We discuss how these observations support the model that mitotic condensation is a deterministic process leading to the invariant folding of a given chromosome. The structural studies have also placed constraints on the mechanism of condensation and defined several activities needed to mediate condensation. In the context of these activities and structural information, we present our current understanding of the role of cis sites, histones, topoisomerase II, and SMC proteins in condensation. We conclude by using our current knowledge of mitotic condensation to address the differences in chromosome condensation observed from bacteria to humans and to explore the relevance of this process to other processes such as gene expression.

References

Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·T Igó-Kemenes, H G Zachau
Aug 1, 1979·Cell·M P Marsden, U K Laemmli
Nov 1, 1977·Cell·J R Paulson, U K Laemmli
Jan 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E M Bradbury
Jun 1, 1992·The Journal of Cell Biology·F KleinS M Gasser
Mar 1, 1992·Trends in Biochemical Sciences·S Y Roth, C D Allis
Sep 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Hernandez, C Martinez del Rio
Dec 1, 1991·The Journal of Cell Biology·T Hirano, T J Mitchison
Jun 1, 1991·Current Opinion in Cell Biology·M M Smith
Feb 22, 1991·Cell·M BaumgartnerE Viegas-Péquignot
Jan 1, 1989·Molecular and Cellular Biology·C HolmD Botstein
Jul 20, 1989·Journal of Molecular Biology·R A Kim, J C Wang
Nov 1, 1989·Chromosoma·P B Moens, W C Earnshaw
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ Gray
May 1, 1985·The Journal of Cell Biology·W C EarnshawL F Liu
May 1, 1985·The Journal of Cell Biology·W C Earnshaw, M M Heck
Jul 10, 1987·Nucleic Acids Research·K RostasR G Lloyd
Mar 5, 1988·Journal of Molecular Biology·J MirkovitchU K Laemmli
Dec 1, 1987·Molecular & General Genetics : MGG·D R Gill, G P Salmond
May 1, 1980·Cell·K N Kreuzer, N R Cozzarelli

❮ Previous
Next ❯

Citations

Feb 15, 2001·Journal of Cellular Physiology·G SunE Kardami
May 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michelle F Pflumm
Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Losada, T Hirano
Sep 21, 2012·Chromosoma·Jeffrey P ChmielewskiTim W Christensen
Oct 20, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Juan Manuel CaravacaJoan-Ramon Daban
Mar 25, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Damien F HudsonWilliam C Earnshaw
Aug 29, 2012·Cell Biochemistry and Biophysics·Kavindra Kumar KesariJitendra Behari
Jun 26, 1998·Current Opinion in Cell Biology·T Hirano
Jan 23, 1999·Current Opinion in Cell Biology·S Biggins, A W Murray
Jun 4, 1998·Current Opinion in Genetics & Development·R JessbergerS M Gasser
Jul 24, 1998·Trends in Microbiology·W Margolin
Nov 17, 2009·Nature Structural & Molecular Biology·Ai TakemotoKeiji Kimura
Nov 7, 2007·Nature Structural & Molecular Biology·Sukesh R BhaumikAli Shilatifard
Jul 25, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M M SlupskaJ H Miller
Feb 16, 2002·The Plant Journal : for Cell and Molecular Biology·Chun-ming Liu CmDavid Meinke
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y WeiC D Allis
Jun 13, 2009·The Journal of Biological Chemistry·Chi Kwan Tsang, X F Steven Zheng
Apr 22, 2005·The Journal of Biological Chemistry·Rada PhilipovaMichael Whitaker
Aug 13, 2002·Cloning and Stem Cells·Björn Oback, David Wells
Sep 29, 2011·DNA and Cell Biology·Gyorgy TrencsenyiGaspar Banfalvi
Feb 21, 2002·Molecular Biology of the Cell·Jing Yu, Mariana F Wolfner
Apr 6, 2000·Molecular Biology of the Cell·I I OuspenskiB R Brinkley
Nov 15, 1997·Molecular Biology of the Cell·J F Marko, E D Siggia
Nov 17, 2009·Molecular Biology of the Cell·Osamu IwasakiKen-Ichi Noma
Feb 2, 2000·The EMBO Journal·A E de la BarreS Dimitrov
Mar 30, 2007·Nucleic Acids Research·Ai TakemotoKeiji Kimura
Oct 7, 2010·Nucleic Acids Research·Veronica Gomez-GodinezMichael W Berns

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
dissection
electron microscopy
scanning electron microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.