PMID: 20109572DOI: 10.1016/j.semcdb.2010.01.019Jan 30, 2010Paper
Mitotic functions of kinesin-5.
Seminars in Cell & Developmental Biology
Nick P FerenzPat Wadsworth
Abstract
In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the mitotic spindle. Analysis of live cells further shows that kinesin-5 motors are highly dynamic in the spindle. Understanding the interactions of kinesin-5 motors with microtubules and other spindle proteins is likely to broaden the documented roles of kinesin-5 motors during cell division.
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