Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes

Molecular Cancer Research : MCR
Sayyed K ZaidiGary S Stein

Abstract

Reconfiguration of nuclear structure and function during mitosis presents a significant challenge to resume the next cell cycle in the progeny cells without compromising structural and functional identity of the cells. Equally important is the requirement for cancer cells to retain the transformed phenotype, that is, unrestricted proliferative potential, suppression of cell phenotype, and activation of oncogenic pathways. Mitotic gene bookmarking retention of key regulatory proteins that include sequence-specific transcription factors, chromatin-modifying factors, and components of RNA Pol (RNAP) I and II regulatory machineries at gene loci on mitotic chromosomes plays key roles in coordinate control of cell phenotype, growth, and proliferation postmitotically. There is growing recognition that three distinct protein types, mechanistically, play obligatory roles in mitotic gene bookmarking: (i) Retention of phenotypic transcription factors on mitotic chromosomes is essential to sustain lineage commitment; (ii) Select chromatin modifiers and posttranslational histone modifications/variants retain competency of mitotic chromatin for gene reactivation as cells exit mitosis; and (iii) Functional components of RNAP I and II transcri...Continue Reading

References

Feb 1, 1993·The Journal of Cell Biology·P HartlD J Forbes
Apr 1, 1996·The Journal of Cell Biology·P RousselD Hernandez-Verdun
Jun 1, 1997·Trends in Biochemical Sciences·J M Gottesfeld, D J Forbes
Aug 28, 1997·Nature·E F MichelottiD Levens
Jun 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S John, J L Workman
Feb 16, 2002·Science·Job DekkerNancy Kleckner
Apr 12, 2003·Journal of Cellular Biochemistry·Florian OttoMichael Stock
Apr 18, 2003·Nature·Jonathan M ScholeyAlex Mogilner
Jul 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anup DeyKeiko Ozato
Mar 1, 1962·Experimental Cell Research·D M PRESCOTT, M A BENDER
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sayyed K ZaidiGary S Stein
May 25, 2004·Oncogene·Luke F Peterson, Dong-Er Zhang
Nov 20, 2004·EMBO Reports·Hariharan P EaswaranM Cristina Cardoso
Jan 22, 2005·Science·Hongyan XingKevin D Sarge
Sep 29, 2005·Trends in Biochemical Sciences·Kevin D Sarge, Ok-Kyong Park-Sarge
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel W YoungGary S Stein
May 25, 2007·Nature Reviews. Cancer·Sayyed K ZaidiGary S Stein
Dec 7, 2007·Genes & Development·Robert Schneider, Rudolf Grosschedl
May 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Syed A AliJanet L Stein
Feb 18, 2009·Cell Cycle·Kevin D Sarge, Ok-Kyong Park-Sarge
Oct 9, 2009·Molecular Biology of the Cell·Anup DeyKeiko Ozato
Nov 7, 2009·Diagnostic Cytopathology·Pranab Dey
Nov 21, 2009·The Journal of Pathology·Elliott Lever, Denise Sheer
Dec 8, 2009·Nature Medicine·Francisco VerdeguerMarco Pontoglio
Dec 17, 2009·The Journal of Cell Biology·Hideki YokoyamaEric Karsenti
Jul 16, 2010·Nature Reviews. Genetics·Sayyed K ZaidiGary S Stein
Aug 10, 2010·Methods in Molecular Biology·Sayyed K ZaidiGary S Stein
Oct 27, 2010·Current Opinion in Cell Biology·Shinya OhtaWilliam C Earnshaw
Jan 29, 2011·Cell Cycle·Theresa K Kelly, Peter A Jones
May 1, 2012·Current Opinion in Cell Biology·Miroslav Dundr
May 4, 2012·Journal of Cellular Physiology·Kristina KapinasGary Stein
Jan 11, 2013·Nucleic Acids Research·Panagiota ArampatziJoseph Papamatheakis
Jan 29, 2013·Genes & Development·Juan Manuel CaravacaKenneth S Zaret
Mar 12, 2013·Molecular Cell·Johan H Gibcus, Job Dekker
Apr 4, 2013·Epigenetics & Chromatin·Stephan Kadauke, Gerd A Blobel

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