PMID: 7035826Jan 1, 1981Paper

Mitotic recombination: mismatch correction and replicational resolution of Holliday structures formed at the two strand stage in Saccharomyces

Molecular & General Genetics : MGG
J Golin, M S Esposito

Abstract

In a preliminary report (Esposito 1978), evidence was presented which showed that heteroallelic recombination resulting in prototrophic colonies occurs at the 2-strand stage. A model utilizing replicative resolution of Holliday structures was proposed to explain how gene conversion at the 2-strand stage can result in exchange of outside markers. The object of the experiments reported herein was to present detailed genetic evidence for 2-strand recombination. In addition, we examined the features of mitotic recombination with respect to symmetry, length and polarity of heteroduplexes in wild type strains (REM1/REM1) and in strains bearing the hyper-recombination mutation rem1-1. To do this, we constructed strains so that prototrophs arising from heteroallelic recombination and recombinant for outside markers were detected by visual inspection. By analyzing these colonies genetically, we have inferred several features of mitotic recombination which distinguish it from its meiotic counterpart. Firstly, mitotic heteroduplexes are often symmetric while meiotic heteroduplexes are almost exclusively asymmetric. Secondly, heteroduplexes tend to be longer in mitosis that in meiosis. Thirdly, unlike meiotic conversion, mitotic conversion...Continue Reading

References

Jan 1, 1978·Annual Review of Biochemistry·C M Radding
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·S FogelF Tavares
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M S Esposito
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M S Meselson, C M Radding
Jan 1, 1973·Annual Review of Genetics·D R Stadler
Oct 1, 1971·Genetical Research·R J Thornton, J R Johnston
Apr 1, 1970·American Journal of Surgery·E H Drake
Apr 1, 1980·Current Genetics·R E MaloneM S Esposito
Dec 1, 1949·Journal of Genetics·D E LEA, C A COULSON

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Citations

May 1, 1993·Current Genetics·M S Esposito, C V Bruschi
Jul 1, 1990·Current Genetics·C B McGillJ N Strathern
Jan 1, 1984·Molecular & General Genetics : MGG·F FabreH Roman
Jan 1, 1983·Molecular & General Genetics : MGG·S L KellyJ M Parry
Jan 1, 1994·Current Genetics·M S EspositoC V Bruschi
Sep 1, 1988·Trends in Genetics : TIG·G S Roeder, S E Stewart
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H Roman, F Fabre
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C V Bruschi, M S Esposito
Oct 1, 1990·Molecular Microbiology·R Piñón
May 2, 2002·Molecular Cell·Walter W SteinerGerald R Smith
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jakob GebelVolker Dötsch
Nov 16, 2001·Journal of Theoretical Biology·I P Gorlov, O Y Gorlova
Dec 1, 1988·Molecular and Cellular Biology·T L Orr-WeaverJ W Szostak
Apr 1, 1991·Molecular and Cellular Biology·K J Dornfeld, D M Livingston
Mar 1, 1985·Microbiological Reviews·T L Orr-Weaver, J W Szostak
Apr 1, 1992·Molecular and Cellular Biology·R J BollagR M Liskay

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