Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer

Cancer Investigation
J HarveyR Ghalie

Abstract

This study evaluated mitoxantrone and paclitaxel combination chemotherapy in the treatment of patients with metastatic breast cancer. Thirty-seven patients who had developed progressive disease after prior chemotherapy were treated with mitoxantrone (14 mg/m2) and paclitaxel (150 mg/m2) every 21 days for a maximum of six cycles. The most frequent grade 3 or 4 nonhematological toxicities were fever and nausea. Grade 4 neutropenia occurred in 71% of patients. Cardiotoxicity occurred in 2 patients, both of whom had previously received doxorubicin. Objective response was achieved in 35% of patients (5% complete response and 30% partial response) and 41% had stable disease. Median time to disease progression and median survival were 6 and 12 months, respectively. The percent of patients with an objective response was not different for those who had received prior doxorubicin or had chemotherapy in the preceding 6 months. This regimen appears to be effective and well tolerated as salvage therapy and merits further evaluation.

References

Dec 18, 1991·Journal of the National Cancer Institute·F A HolmesG N Hortobagyi
Oct 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D HainsworthF A Greco
Jan 1, 1990·Cancer Investigation·J A AjaniI H Krakoff
May 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I C HendersonD Henry
May 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H SchipperM Levitt
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanJ Crown
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D HainsworthF A Greco
Sep 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J GehlP Dombernowsky
Oct 1, 1998·The New England Journal of Medicine·G N Hortobagyi
Oct 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R FossatiA Liberati

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Citations

Oct 21, 2004·Cancer Investigation·Francesco Di CostanzoUNKNOWN Italian Oncology Group for Cancer Research
Jul 26, 2014·Archives of Pharmacal Research·Monika LepiarczykKrzysztof Bielawski

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