DOI: 10.1101/489955Dec 7, 2018Paper

MitoZ: A toolkit for mitochondrial genome assembly, annotation and visualization

BioRxiv : the Preprint Server for Biology
Guanliang MengShanlin Liu


Mitochondrial genome (mitogenome) plays important roles in evolutionary and ecological studies. It becomes routine to utilize multiple genes on mitogenome or the entire mitogenomes to investigate phylogeny and biodiversity of focal groups with the onset of High Throughput Sequencing technologies. We developed a mitogenome toolkit MitoZ, consisting of independent modules of de novo assembly, findMitoScaf, annotation and visualization, that can generate mitogenome assembly together with annotation and visualization results from HTS raw reads. We evaluated its performance using a total of 50 samples of which mitogenomes are publicly available. The results showed that MitoZ can recover more full-length mitogenomes with higher accuracy compared to the other available mitogenome assemblers. Overall, MitoZ provides a one-click solution to construct the annotated mitogenome from HTS raw data and will facilitate large scale ecological and evolutionary studies. MitoZ is free open source software distributed under GPLv3 license and available at

Related Concepts

Biological Evolution
Computer Software
Molecular Assembly/Self Assembly
Mitochondrial Inheritance
Population Based Study
Genome, Mitochondrial
Hypotrichosis Simplex

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