Mitral annular calcification predicts mortality and coronary artery disease in end stage renal disease

Atherosclerosis
Rajan SharmaStephen J D Brecker

Abstract

We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was defined as luminal stenosis >70% by visual estimation in at least one coronary artery. There were 21 deaths over a follow-up period of 2.2+/-0.7 years. MAC occurred in 56 patients (40%) and was associated with higher mortality (p=0.04). Patients with MAC were older (p=or<0.001), had larger left ventricular (LV) end systolic (p=0.005) and LV end diastolic (p=0.04) diameter, larger left atrial diameter (p=0.001), lower LV fractional shortening (p=0.003), larger LV mass index (p=0.04) and higher mitral E/Ea ratio (p=0.03) compared to those without. Plasma calcium (p=0.002), phosphate (p=0.004), cardiac troponin T (p=0.03), N-terminal Pro-B-type natriuretic peptide (p=0.004) concentrations were higher in those with MAC but gender, total cholesterol, haemoglobin and creatinine were similar in the two groups. The proportion diabetic (p=0.03), on dialysis (p=0.05), with significant CAD (p=or<0.001), taking calcium containing phosphate binde...Continue Reading

References

Aug 6, 1992·The New England Journal of Medicine·E J BenjaminD Levy
Sep 1, 1994·Cleveland Clinic Journal of Medicine·W E Braun, T H Marwick
Jul 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P S ParfreyP E Barre
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E McGregorJ D Briggs
Aug 27, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S RibeiroF Ribeiro
May 18, 2000·The New England Journal of Medicine·W G GoodmanI B Salusky
Feb 19, 2002·Journal of the American College of Cardiology·Paolo RaggiGlenn M Chertow
Jun 26, 2002·Kidney International·Glenn M ChertowUNKNOWN Treat to Goal Working Group
Mar 26, 2003·Circulation·Caroline S FoxUNKNOWN Framingham Heart Study
Apr 6, 2004·Atherosclerosis·Caroline S FoxEmelia J Benjamin
Apr 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Glenn M ChertowSteven K Burke
Jun 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ali A HaydarDavid J A Goldsmith
Jul 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rajan SharmaStephen J D Brecker
Dec 31, 2005·Journal of the American Society of Nephrology : JASN·Caroline S FoxEmelia J Benjamin

❮ Previous
Next ❯

Citations

Feb 2, 2011·Nature Reviews. Nephrology·M Khaled Shamseddin, Patrick S Parfrey
Oct 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Folkert W AsselbergsDavid S Siscovick
Apr 26, 2012·Current Opinion in Nephrology and Hypertension·Antonio Bellasi, Paolo Raggi
Apr 9, 2009·Transplantation·Grainne M ConnollyAlexander P Maxwell
Mar 19, 2013·Journal of Cardiothoracic Surgery·Qiu ZhibingWang LiMing
Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Paolo RaggiPaul Muntner
Mar 26, 2013·Nutrients·Masanori AbeMasayoshi Soma
Mar 20, 2014·Nephron. Clinical Practice·Haotian GuJohn Chambers
Apr 23, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Diana Y Y ChiuPhilip A Kalra
Jul 31, 2013·Expert Review of Cardiovascular Therapy·George LazarosNalini Rajamannan
Nov 12, 2013·Archives of Medical Research·Marcela Avila-DíazRamón Paniagua
Jul 24, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rajesh MovvaGregg S Pressman
Nov 6, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hiroshi TakahashiYukio Yuzawa
Jan 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Anupama K RaoJames H Stein
Feb 26, 2011·The American Journal of Cardiology·Yasmin S HamiraniMatthew Budoff
Oct 10, 2013·BioMed Research International·Gregg S PressmanVincent M Figueredo
Jan 1, 2013·Atherosclerosis·Atif N QasimMuredach P Reilly
Oct 16, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marvin Louis Roy LuGregg S Pressman
Mar 24, 2017·Seminars in Dialysis·Paolo Raggi, W Charles O'Neill
May 5, 2016·Circulation·Karan SudSamir R Kapadia
Oct 13, 2017·Journal of the American Heart Association·Zainab SamadEric J Velazquez
Feb 2, 2019·Circulation. Cardiovascular Interventions·Binita ShahMathew R Williams
Apr 22, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadia El HangoucheRami Doukky
Jul 12, 2019·Experimental & Molecular Medicine·Jia GuXiangqing Kong
Feb 9, 2020·Current Atherosclerosis Reports·Luiz Rafael P CavalcantiRicardo C Lima
Sep 27, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Jayson Rakesh BamanJames D Flaherty
Nov 6, 2018·The Journal of Thoracic and Cardiovascular Surgery·Kareem BedeirSary Aranki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.