Mixed Adenoma Well-differentiated Neuroendocrine Tumor (MANET) of the Digestive System: An Indolent Subtype of Mixed Neuroendocrine-NonNeuroendocrine Neoplasm (MiNEN)

The American Journal of Surgical Pathology
Stefano La RosaMassimo Bongiovanni

Abstract

Mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) consisting of adenoma and well-differentiated neuroendocrine tumor (NET) has been recently defined as "MANET." However, the clinico-pathologic and pathogenetic features of this entity are not thoroughly studied. We examined the clinico-pathologic features of 12 MANETs by expanding their p53 and β-catenin expression profiles as well as the presence of microsatellite instability and KRAS, BRAF, and PIK3CA mutations in the 2 tumor components. In all cases, the adenomatous component represented the larger part of the lesions and the NET was localized in the deep central portion of polyps. In 9 cases the latter was represented by NET G1, in 2 by NET G2, and in 1 by NET G3. In all cases, the glandular and NET components were intimately admixed, with zone of transition between the tumor components. The NET component was p53 negative in all cases and 3 of 8 cases showed variable nuclear positivity for β-catenin. All patients with follow-up data were alive and free of disease after a mean follow-up time of 9 years. No mutations in KRAS, BRAF, and PIK3CA genes and no microsatellite instability were found in both tumor components. Review of the literature also identified 59 previousl...Continue Reading

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Citations

Jan 23, 2020·Journal of Clinical Medicine·Melissa FrizzieroMairéad G McNamara
Oct 3, 2020·Virchows Archiv : an International Journal of Pathology·Marco Schiavo LenaClaudio Doglioni
Sep 29, 2020·World Journal of Gastroenterology : WJG·Rani KanthanSelliah C Kanthan
Jul 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Kiyohiko SakataMotohiro Morioka
Sep 28, 2020·Histopathology·Parag D DabirIris D Nagtegaal
Dec 15, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Anna NießenOliver Strobel
Dec 22, 2020·World Journal of Clinical Cases·Shuzo KohnoKazuhiko Yoshida
Feb 25, 2020·Pathology, Research and Practice·Federica GrilloLuca Mastracci
Mar 10, 2021·Pathologica·Luca MastracciStefano La Rosa
Apr 17, 2021·Case Reports in Oncological Medicine·Santiago TeranJuan Antonio Nuñez Sobrino
Sep 10, 2021·Virchows Archiv : an International Journal of Pathology·Atsuko KasajimaGünter Klöppel

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Methods Mentioned

BETA
laser capture microdissection
biopsy

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