Mixed ceria-based metal oxides biosensor for operation in oxygen restrictive environments

Analytical Chemistry
John NjagiSilvana Andreescu

Abstract

The unique catalytic, electrochemical, and oxygen storage properties of ceria and mixed ceria/titania hybrid composites were used to fabricate a new type of electrochemical enzyme biosensor. These materials provided increased analytical performance and possibilities for operation in oxygen-free conditions of an oxidase enzyme biosensor using tyrosinase as a model example. The investigation of the enzymatic reaction in the presence and absence of oxygen was first carried out using cyclic voltammetry. The results were used to identify the role of each metal oxide in the immobilization matrix and fabricate a simple amperometric tyrosinase biosensor for the detection of phenol and dopamine. The biosensor was optimized and characterized with respect to response time, detection limit, linear concentration range, sensitivity, and kinetic parameters. The detection limit for phenol was in the nanomolar range, with a detection limit of 9.0 x 10(-9) M and a sensitivity of 86 mA M(-1) in the presence of oxygen and of 5.6 x 10(-9) M and a sensitivity of 65 mA M(-1) in the absence of oxygen. The optimized biosensor also showed selective determination of the neurotransmitter dopamine with a detection limit of 3.4 x 10(-8) M and a sensitivity ...Continue Reading

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Citations

Dec 18, 2012·Analytical and Bioanalytical Chemistry·Krystyna Jackowska, Pawel Krysinski
Feb 7, 2016·Analytica Chimica Acta·Aytekin Uzunoglu, Lia A Stanciu
Mar 19, 2014·Environmental Science. Nano·Rıfat Emrah OzelSilvana Andreescu
Jan 9, 2010·Analytical Chemistry·John NjagiSilvana Andreescu
Apr 29, 2011·Analytical Chemistry·Maryna OrnatskaSilvana Andreescu
Jun 13, 2014·Chemical Reviews·Jing Bai, Baoxue Zhou
Sep 24, 2013·Analytical Chemistry·Akhtar Hayat, Silvana Andreescu
Jan 21, 2017·Analytical Chemistry·Tongfang XiaoLanqun Mao

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