PMID: 9185904Jun 1, 1997Paper

Mixed connective tissue disease. A clinical, histologic, and immunofluorescence study of eight cases

The American Journal of Dermatopathology
Cynthia M MagroS Regauer

Abstract

A study of the cutaneous eruptions of eight patients with mixed connective tissue disease (MCTD) was performed to better characterize its dermatopathology and to explore a role for the membrane attack complex of complement C5b-9 in lesional pathogenesis. Nine lesional skin biopsies were obtained from eight patients with MCTD and analyzed by conventional light microscopy. Direct immunofluorescence (IF) and indirect IF using a monoclonal antibody to C5b-9 were applied in six and five cases respectively. The biopsied cutaneous eruptions were characterized clinically as photo-distributed erythematosus annular and/or papulosquamous lesions mimnicking subacute cutaneous lupus erythematosus (SCLE) in five of eight patients as an ill-defined, telangiectatic, scaly patch on the face in one patient, palpable purpura in one patient, and dorsal hand blisters resembling porphyria cutanea tarda (PCT) in another. With the exception of the latter two patients, the histology appeared similar, comprising a cell poor and/or lichenoid interface dermatitis with suprabasilar exocytosis around necrotic keratinocytes in the absence of deep periadnexal or perivascular extension or conspicuous follicular plugging, a pattern similar to that of SCLE. Howe...Continue Reading

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W P Kolb, H J Müller-Eberhard
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M R Lerner, J A Steitz
Oct 1, 1992·British Journal of Rheumatology·C Black, D A Isenberg
Jun 1, 1992·Australian and New Zealand Journal of Medicine·A Sturgess
Sep 1, 1991·Immunology Today·T Kinoshita
Jul 1, 1991·International Journal of Dermatology·R M Fine
Jul 1, 1991·The British Journal of Dermatology·M S KoelleT P Chorzelski
Apr 1, 1991·Seminars in Arthritis and Rheumatism·R A AshersonG R Hughes
Jan 31, 1989·Immunology Letters·E BodolayN R Farid
May 1, 1988·The British Journal of Dermatology·C NieboerH E Van Leeuwen-Wallau
Apr 30, 1987·The New England Journal of Medicine·T T ProvostM Reichlin
Apr 1, 1981·Journal of the American Academy of Dermatology·J N Gilliam, R D Sontheimer
Sep 1, 1981·Journal of the American Academy of Dermatology·J P Callen, L Ross
Sep 1, 1994·Journal of the American Academy of Dermatology·A N Crowson, C M Magro
Nov 1, 1993·The Journal of Infectious Diseases·T L JansenJ M Werre

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Citations

Feb 13, 2001·Journal of Cutaneous Pathology·A N Crowson, C Magro
Dec 17, 2003·Journal of Cutaneous Pathology·Cynthia M MagroMarco Sebastiani
Nov 24, 2006·The American Journal of Dermatopathology·J Andrew Carlson, Ko-Ron Chen
May 25, 2010·Medicinski pregled·Ljiljana Medenica, Dusan Skiljević
Dec 24, 1997·Journal of Cutaneous Pathology·C M Magro, A N Crowson
Apr 3, 1999·Journal of Cutaneous Pathology·C M Magro, A N Crowson
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Thomas Grader-Beck, Fredrick M Wigley

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