PMID: 9643318Jun 27, 1998Paper

Mixed cryoglobulinaemia: a cross-road between autoimmune and lymphoproliferative disorders

Lupus
C FerriG Pasero

Abstract

Mixed cryoglobulinaemia (MC) is a systemic vasculitis, secondary to the deposition in small and medium-sized blood vessels of circulating immune complexes, mainly the cryoglobulins, and complement. MC is characterised by a typical clinical triad (purpura, weakness, arthralgias) and by one or more organ involvement: chronic hepatitis, glomerulonephritis, peripheral neuropathy, skin ulcers and diffuse vasculitis. In a limited number of MC patients, a malignancy, that is B-cell non-Hodgkin's lymphoma or hepatocellular carcinoma, may also develop. Hepatitis C virus (HCV) infection has been found in the majority of patients with MC; the frequency of HCV markers (91%) was significantly higher than other rheumatic diseases (6.4%), namely systemic lupus, Sjögren's syndrome, rheumatoid arthritis and systemic sclerosis, or healthy controls (1.2%). The HCV infection of lymphoid tissues may represent the remote event leading to B-lymphocyte proliferation responsible for autoantibodies and immune-complex production. In a similar way, HCV infection may also be involved in the pathogenesis of other autoimmune (glomerulonephritis, thyroiditis, lung fibrosis, autoimmune hepatitis, porphyria cutanea tarda) and lymphoproliferative disorders (mono...Continue Reading

References

Jun 30, 1977·The New England Journal of Medicine·Y LevoE C Franklin
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S FargionG Fiorelli
Dec 1, 1991·Arthritis and Rheumatism·C FerriS Bombardieri
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C FerriS Bombardieri
Aug 1, 1990·The Journal of Infectious Diseases·M PascualJ A Schifferli
Nov 1, 1989·The American Journal of Medicine·C FerriS Bombardieri
Jun 1, 1988·Clinical Immunology and Immunopathology·G F FioriniG D'Amico
Dec 5, 1970·Lancet·D J GockeC L Christian
Nov 1, 1974·The American Journal of Medicine·J C BrouetM Seligmann
Aug 1, 1980·The American Journal of Medicine·P D GorevicE C Franklin
Mar 1, 1980·Annals of Internal Medicine·J W PoppK J Bloch
Jan 1, 1996·Annals of Internal Medicine·A L ZignegoP Gentilini
Dec 1, 1993·European Journal of Clinical Investigation·C FerriA L Zignego
Nov 1, 1994·European Journal of Clinical Investigation·C FerriS Bombardieri
Oct 15, 1995·Annals of Internal Medicine·S C Gumber, S Chopra
Oct 1, 1994·British Journal of Haematology·C FerriA Mazzoni
Mar 17, 1994·The New England Journal of Medicine·R MisianiG Vendramin
Oct 1, 1993·Arthritis and Rheumatism·G AbelV Agnello
Jul 1, 1993·European Journal of Clinical Investigation·C FerriS Bombardieri
Aug 15, 1996·Annals of Internal Medicine·C FerriA L Zignego
Dec 1, 1995·Arthritis and Rheumatism·L La CivitaC Ferri
Mar 1, 1997·British Journal of Rheumatology·C FerriA L Zignego
Oct 23, 1997·British Journal of Haematology·A L ZignegoC Ferri
Nov 14, 1997·European Journal of Clinical Investigation·C FerriG Pasero
Jan 1, 1962·The American Journal of Medicine·J LOSPALLUTOM ZIFF

❮ Previous
Next ❯

Citations

Feb 17, 2001·Muscle & Nerve·R Rosenbaum
Nov 11, 1999·Arthritis and Rheumatism·A Selva-O'CallaghanM Vilardell-Tarrés
Jan 1, 2000·Arthritis and Rheumatism·P LamprechtW L Gross
Dec 11, 1999·Clinics in Dermatology·A Del RossoM Matucci-Cerinic
Apr 3, 2007·Nature Immunology·Alexander AstrakhanDavid J Rawlings
Jul 15, 2006·Thyroid : Official Journal of the American Thyroid Association·Alessandro AntonelliEle Ferrannini
Jan 23, 1999·Current Opinion in Rheumatology·J Braun, J Sieper
Sep 30, 1999·Current Opinion in Rheumatology·R I FoxP Michelson
Jan 27, 2000·Current Opinion in Rheumatology·C Ferri, A L Zignego
May 1, 2002·Current Opinion in Rheumatology·Alessandra Della RossaStefano Bombardieri
Feb 24, 2001·The Laryngoscope·A C GoldmanJ Lim
Jul 27, 1999·Annals of the Rheumatic Diseases·A Perl
Feb 5, 2002·Journal of Clinical Pathology·C FerriS A Pileri
Jul 16, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anwaar Saeed, Ammar Alkhazna
Aug 3, 2002·Leukemia & Lymphoma·Daniela GasparottoMauro Boiocchi
Mar 1, 2008·Expert Review of Clinical Immunology·Fabrice Jardin
Dec 24, 2014·Expert Review of Clinical Immunology·Anna Linda ZignegoClodoveo Ferri
Mar 18, 2003·The American Journal of the Medical Sciences·Marlyn J Mayo
Jul 16, 2008·Clinics in Liver Disease·Anna Linda Zignego, Antonio Craxì
Jan 8, 2008·Molecular Aspects of Medicine·Antonio CraxìAnna Linda Zignego
Mar 26, 2003·Clinical and Experimental Dermatology·S AndrejevicM M Nikolic
Mar 6, 2009·Geriatrics & Gerontology International·Takafumi OkuraJitsuo Higaki
Oct 16, 2007·International Journal of Cancer. Journal International Du Cancer·John J SpinelliRichard P Gallagher
Feb 14, 2006·The Journal of Dermatology·Lucilla MelaniPaolo Fabbri
Nov 10, 2006·Acta Clinica Belgica·S Cherrier-De WildeJ Arnout
Sep 1, 1999·Seminars in Arthritis and Rheumatism·J E NaschitzD Yeshurun
Jul 6, 2005·La Revue de médecine interne·F JardinH Tilly
Jun 11, 2004·Seminars in Arthritis and Rheumatism·Clodoveo FerriAnna Linda Zignego
Sep 13, 2006·Clinics in Dermatology·Robert I Fox, Alice Y Liu
Feb 19, 2015·BioMed Research International·Federica RomitelliEnrico Di Stasio
Oct 21, 2005·Chest·Jonathan MoormanGuha Krishnaswamy
Apr 29, 2000·Lupus·M Ramos-CasalsJ Font
Nov 14, 2020·Current Opinion in Rheumatology·Marie N Kolopp-Sarda, Pierre Miossec
Jan 3, 2001·Clinics in Dermatology·R I FoxM Stern
Jan 8, 2000·Hematology/oncology Clinics of North America·A Dispenzieri, P D Gorevic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.