Mixed cryoglobulinemia is associated with increased risk for death, or neoplasia in HIV-1 infection

European Journal of Clinical Investigation
T KordossisH M Moutsopoulos

Abstract

Cryoglobulinemia has been reported in several chronic infectious and autoimmune diseases, and in patients with HIV-1 infection. Cryoglobulinemia associated with hepatitis C virus infection is considered a risk factor for the development of neoplasia, especially B-cell non-Hodgkin lymphoma. This study was undertaken to investigate whether the presence of circulating cryoglobulins is associated with survival or development of neoplastic disease in HIV-1 infection. We evaluated 87 unselected consecutive HIV-1 infected patients for the presence of cryoglobulinemia and they were prospectively followed up for a median of 34 months, with clinic visits at 4-month intervals. None of the patients had neoplasia at study entry. Time-to-event analysis for death, neoplasm and B-cell lymphoproliferative disorder were performed with Cox proportional hazards models. Mixed cryoglobulinemia (types II and III) was detected in 24 (28%) of the 87 patients. During the follow up, 12 patients died and 8 developed neoplastic disease. Multivariate analysis showed that circulating cryoglobulins were an independent predictor of death [relative risk (RR), 4.97; 95% confidence intervals (CI), 1.26-19.63] and development of neoplasia (RR, 5.18; 95% CI, 1.23-2...Continue Reading

References

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Feb 27, 1999·Annals of Internal Medicine·A N DimitrakopoulosH M Moutsopoulos
Jan 1, 2000·Arthritis and Rheumatism·P LamprechtW L Gross

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Citations

Mar 5, 2009·Rheumatology·Cristina C BeliznaYehuda Shoenfeld
Feb 13, 2009·Medicina clínica·Francisco F Rodríguez-VidigalAgustín Muñoz-Sanz
Aug 24, 2006·Journal of Medical Virology·Nikolaos KosmasTheodore Kordossis

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