Mixed DPPC/POPC Monolayers: All-atom Molecular Dynamics Simulations and Langmuir Monolayer Experiments

Biochimica Et Biophysica Acta
Agnieszka OlżyńskaLukasz Cwiklik

Abstract

To elucidate the consequences of the saturated-unsaturated nature of lipid surface films, monolayers formed by an equimolar mixture of 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipids are investigated in a wide range of surface pressures. As such mixtures share some features with naturally-occurring surfactants, for example the lung surfactant, the systems are studied at the temperature relevant for human body. All-atom molecular dynamics simulations and Langmuir trough experiments are employed. The binary lipid mixture is compared with the corresponding one-component systems. Atomistic-level alterations of monolayer molecular properties upon lateral compression are scrutinized. These involve elevation of lateral ordering of lipid chains, modulation of chain and headgroup orientation, and reduction of lipid hydration. The presence of the unsaturated POPC in the DPPC/POPC mixture reduces the liquid expanded-liquid condensed coexistence region and moderates the phase transition. Simulations predict that nanoscale lipid de-mixing occurs with small transient DPPC clusters emerging due to local fluctuations of the lateral lipid arrangement. A vertical sorting of lip...Continue Reading

References

Mar 4, 1968·Biochimica Et Biophysica Acta·J C Watkins
Feb 1, 1996·Journal of Molecular Graphics·W HumphreyK Schulten
Nov 14, 1998·Biochimica Et Biophysica Acta·R VeldhuizenF Possmayer
Aug 7, 2002·Current Opinion in Structural Biology·Barbora PiknovaStephen B Hall
Sep 30, 2004·Biophysical Journal·Coralie AlonsoJoseph A Zasadzinski
Apr 28, 2007·The Journal of Chemical Physics·C Vega, E de Miguel
May 10, 2007·The Journal of Physical Chemistry. B·Sukit Leekumjorn, Amadeu K Sum
Jan 18, 2008·Biophysical Journal·Susan L Duncan, Ronald G Larson
Apr 25, 2008·Biochimica Et Biophysica Acta·Yi Y ZuoFred Possmayer
Jun 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·H L Halliday
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Svetlana BaoukinaD Peter Tieleman
Oct 11, 2008·Biophysical Chemistry·Doyle RoseValerie Booth
Oct 22, 2008·Biochimica Et Biophysica Acta·Aurelia R Honerkamp-SmithSarah L Keller
Mar 13, 2009·Physical Chemistry Chemical Physics : PCCP·Cameron LaingD Peter Tieleman
Dec 30, 2009·The Journal of Physical Chemistry. B·Delara Mohammad-AghaieFernando Bresme
Oct 5, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Katherine C ThompsonArwel V Hughes
Mar 16, 2011·Biophysical Journal·Mihaela MihailescuStephen H White
Mar 29, 2011·Biochimica Et Biophysica Acta·Hong ZhangYi Y Zuo
Jul 20, 2011·Biochimica Et Biophysica Acta·Susan L DuncanRonald G Larson
Feb 23, 2012·The Journal of Physical Chemistry. B·Joakim P M Jämbeck, Alexander P Lyubartsev
Dec 4, 2012·Biochimica Et Biophysica Acta·Victoria GossAnthony D Postle
May 16, 2013·The Journal of Membrane Biology·Anita WnętrzakPatrycja Dynarowicz-Łątka
Jul 23, 2013·Biochimica Et Biophysica Acta·Jorge Bernardino de la SernaLuis A Bagatolli
Jan 9, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Lucie HuynhNadège Jamin
Sep 5, 2014·Biophysical Journal·Svetlana BaoukinaD Peter Tieleman
Feb 24, 2016·Biochimica Et Biophysica Acta·Lukasz Cwiklik

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Citations

Feb 24, 2017·Chemistry : a European Journal·Anna Stachowicz-KuśnierzJacek Korchowiec
Sep 22, 2018·Physical Chemistry Chemical Physics : PCCP·A Stachowicz-KuśnierzB Korchowiec
Dec 22, 2020·Biophysical Chemistry·V MiguelD A García
Nov 11, 2019·Biochimica Et Biophysica Acta. Biomembranes·Filip DušaSusanne K Wiedmer
Apr 23, 2021·Colloids and Surfaces. B, Biointerfaces·Mateus D MaximinoPriscila Aléssio
Dec 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Matti JavanainenHeather C Allen
Sep 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·S PanzuelaE Velasco
Sep 26, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Matti JavanainenO H Samuli Ollila
Jan 7, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Agnieszka OlżyńskaLukasz Cwiklik
Apr 4, 2020·Biochimica Et Biophysica Acta. Biomembranes·Agnieszka OlżyńskaLukasz Cwiklik
Sep 26, 2021·Biophysical Journal·Yongzheng ZhuGuoqing Hu
Oct 23, 2021·ACS Applied Materials & Interfaces·Eider Berganza, Michael Hirtz

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