Mixed germ cell sex cord-stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases

Virchows Archiv : an International Journal of Pathology
Michal MichalAlexander Talerman

Abstract

We present the morphological, immunohistochemical, and molecular genetic features of three cases of testicular and four cases of ovarian mixed germ cell sex cord-stromal tumors (MGSCT). The germ cells in the testicular MGSCTs morphologically differed from those in classical seminomas by lacking the typical "square off" quality of the nuclei. In contrast to the nuclei in classical seminomas, their size in testicular MGSCTs was smaller and nucleoli were inconspicuous and the cytoplasm was Periodic Acid-Schiff (PAS) negative. Quite on the contrary, the variability in the size of the nuclei of the germ cells in the testicular MGSCTs was more similar to that seen in the germ cells of spermatocytic seminomas. Immunohistochemically, the germ cells of MGSCTs in one case reacted positively with antibody to AE1-AE3 by paranuclear dot-like or rodlike positivity. All three testicular MGSCTs had a negative reaction with the rest of antibodies, including placental alkaline phosphatase (PLAP), OCT4, and c-kit protein. Ovarian MGSCT in our series differed from the testicular lesions in both the germ cell component and the sex cord component. The germ cells in all four ovarian cases had cytomorphological and immunohistochemical features identic...Continue Reading

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Citations

Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Aleksander Talerman, Lawrence M Roth
Jun 2, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Martin C ChangMarisa R Nucci
Jan 18, 2013·Diseases of Aquatic Organisms·J Díaz-DelgadoA Fernández
Apr 13, 2010·Human Pathology·Fredrik PeterssonMichal Michal
Jun 25, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lawrence M Roth, Liang Cheng
Jul 28, 2016·Journal of Clinical Pathology·Lawrence M Roth, Liang Cheng
Oct 5, 2007·International Journal of Surgical Pathology·Michal MichalTomás Vanecek
Nov 17, 2006·Virchows Archiv : an International Journal of Pathology·Thomas M Ulbright, Robert H Young
Sep 14, 2007·Virchows Archiv : an International Journal of Pathology·Michal MichalDmitry V Kazakov
Apr 16, 2010·Virchows Archiv : an International Journal of Pathology·Ondrej DaumMichal Michal
Jun 18, 2020·Virchows Archiv : an International Journal of Pathology·J Wolter Oosterhuis
Apr 17, 2021·Pathology, Research and Practice·Lawrence M RothLiang Cheng

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