Mixed infections of Mycobacterium tuberculosis in tuberculosis patients in Shanghai, China.

Tuberculosis
Rendong FangQian Gao

Abstract

We applied a 7 loci Variable-Number-Tandem-Repeats (VNTR-7) analysis method to identify mixed infections of Mycobacterium tuberculosis and to estimate the rate of mixed infections among pulmonary tuberculosis patients in Shanghai, China. We validated the VNTR-7 method and used it to genotype an isolate from each of the 249 from pulmonary tuberculosis patients reported from the Songjiang and Chongming districts in Shanghai during 2006. We identified 14 patients with mixed infections, and the estimated rate of mixed infections was 5.6% (14/249) (95% CI 3.1%-9.2%). Mixed infections were observed more frequently among tuberculosis patients undergoing retreatment (15.6%) than among new cases (4.1%) (p<0.05), and among tuberculosis patients whose disease was caused by non-Beijing genotype strains (12.5%) versus Beijing genotype strains (3.5%) (p<0.05). The VNTR-7 method is a highly sensitive, practical tool with relatively high discriminatory power, making it useful for studying mixed infections.

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Citations

Mar 15, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Li LiangHeping Xiao
Oct 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-Y WangUNKNOWN TAMI Group
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Mar 24, 2017·Pathogens and Disease·Amanda McIvorBavesh Davandra Kana
May 13, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abigail L MansonAshlee M Earl
Apr 24, 2015·Journal of Clinical Microbiology·Chao ZhengQun Sun
Aug 16, 2018·BMC Genomics·Benjamin SobkowiakTaane G Clark
Jan 8, 2021·Frontiers in Genetics·Alexander Stephen ByrneKapil Tahlan
Dec 5, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Michael Asare-BaahMichael Lauzardo

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