Mixed Langerhans cell and interstitial/dermal dendritic cell subsets emanating from monocytes in Th2-mediated inflammatory conditions respond differently to proinflammatory stimuli

Journal of Leukocyte Biology
Nicolas BechetoilleC Dezutter-Dambuyant

Abstract

The skin harbors two dendritic cell (DC) subsets, Langerhans cells (LC) and interstitial/dermal DC (IDDC), which traffic to lymph nodes after inflammation and ultraviolet stress. To demonstrate that monocytes may act as DC precursors for skin DC in postinflammatory recolonization, we generated LC and IDDC from monocytes by using cytokines related to the T helper cell type 2 environment [granulocyte macrophage-colony stimulating factor/transforming growth factor-beta/interleukin-13/tumor necrosis factor alpha (GM-CSF/TGF-beta/IL-13/TNF-alpha)]. In this study, skin DC [LC as Langerin/CD207(+) cells and IDDC as DC-specific intercellular adhesion molecule-grabbing nonintegrin (SIGN)/CD209(+) cells] displayed desynchronized programs along their differentiation, activation/maturation processes in response to stimuli characteristics of a proinflammatory context. First, we demonstrate that monocytes are able to diverge simultaneously along two distinct pathways toward Langerin(+)-LC-type DC and DC-SIGN(+)-IDDC. Second, as TGF-beta is known to antagonize the TNF-alpha-induced maturation process of DC, we showed that IDDC did not mature and acquired a low CC chemokine receptor 7 (CCR7) receptor expression even when stimulated with prolon...Continue Reading

Citations

Feb 29, 2008·Annual Review of Immunology·Natalya V SerbinaEric G Pamer
Jan 1, 2010·Advances in Virology·Sansanee NoisakranGuey Chuen Perng
Apr 25, 2008·The Journal of Investigative Dermatology·Chizuko KogaYoshiki Tokura
May 12, 2007·Toxicology and Applied Pharmacology·Cindy A RyanG Frank Gerberick
Jan 8, 2009·Contact Dermatitis·Mascha J ToebakThomas Rustemeyer
Oct 17, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yohei OtsukaHidemi Takahashi
Jan 26, 2021·Médecine sciences : M/S·Quentin MullerVincent Flacher

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