Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer

Genes & Cancer
Ajay RanaAnumantha Kanthasamy

Abstract

Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are yet unknown. However, MLKs in general have been implicated in neurodegenerative diseases, including Parkinson and Alzheimer diseases. Recent reports suggest that some of the MLK members could play a role in cancer via modulating cell migration, invasion, cell cycle, and apoptosis. This review article will first describe the biology of MLK members and then discuss the current progress that relates to their functions in cancer.

Citations

Dec 2, 2014·Molecular Medicine Reports·Bicheng ZhangJianfei Gao
Feb 24, 2015·Apoptosis : an International Journal on Programmed Cell Death·Sehamuddin GaladariFaisal Thayyullathil
May 24, 2016·Cancers·Chotirat Rattanasinchai, Kathleen A Gallo
Apr 16, 2015·PloS One·Lingyu LuoZhijun Luo
Jul 8, 2018·The Journal of Biological Chemistry·Malgorzata E KokoszkaBrian K Kay
Mar 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sandeep KumarAjay Rana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Canadian Journal of Physiology and Pharmacology
Deborah N Chadee
International Journal of Experimental Pathology
Matthew E HandleyDavid R Katz
Biochimica Et Biophysica Acta
Eun Kyung Kim, Eui-Ju Choi
Nature Reviews. Molecular Cell Biology
Kathleen A Gallo, Gary L Johnson
© 2021 Meta ULC. All rights reserved