Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13

The FEBS Journal
Khairul I AnsariSubhrangsu S Mandal

Abstract

HOXC13, a homeobox-containing gene, is involved in hair development and human leukemia. The regulatory mechanism that drives HOXC13 expression is mostly unknown. Our studies have demonstrated that HOXC13 is transcriptionally activated by the steroid hormone estrogen (17beta-estradiol; E2). The HOXC13 promoter contains several estrogen-response elements (EREs), including ERE1 and ERE2, which are close to the transcription start site, and are associated with E2-mediated activation of HOXC13. Knockdown of the estrogen receptors (ERs) ERalpha and ERbeta suppressed E2-mediated activation of HOXC13. Similarly, knockdown of mixed lineage leukemia histone methylase (MLL)3 suppressed E2-induced activation of HOXC13. MLLs (MLL1-MLL4) were bound to the HOXC13 promoter in an E2-dependent manner. Knockdown of either ERalpha or ERbeta affected the E2-dependent binding of MLLs (MLL1-MLL4) into HOXC13 EREs, suggesting critical roles of ERs in recruiting MLLs in the HOXC13 promoter. Overall, our studies have demonstrated that HOXC13 is transcriptionally regulated by E2 and MLLs, which, in coordination with ERalpha and ERbeta, play critical roles in this process. Although MLLs are known to regulate HOX genes, the roles of MLLs in hormone-mediate...Continue Reading

References

May 1, 1996·Stem Cells·H J LawrenceC Largman
Feb 1, 1996·Biology of Reproduction·J F StraussM Kiriakidou
Feb 16, 2000·The Journal of Investigative Dermatology. Symposium Proceedings·A R Godwin, M R Capecchi
Aug 11, 2001·Science·T Jenuwein, C D Allis
Oct 3, 2001·Physiological Reviews·S NilssonJ A Gustafsson
Jan 24, 2002·The Journal of Biological Chemistry·Nevan J KroganAli Shilatifard
Aug 2, 2002·Trends in Biochemical Sciences·Robert SchneiderTony Kouzarides
Mar 6, 2003·Genes, Chromosomes & Cancer·Roberta La StarzaCristina Mecucci
Mar 19, 2003·Critical Reviews in Eukaryotic Gene Expression·Stefan Nilsson, Jan-Ake Gustafsson
May 14, 2003·Die Naturwissenschaften·Alexander Awgulewitsch
Oct 3, 2003·Nature·Wolfgang FischleC David Allis
Dec 9, 2003·Nature Cell Biology·Robert SchneiderTony Kouzarides
Jan 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lih-Wen DengJack L Strominger
Feb 21, 2004·Methods in Enzymology·Andrew J Bannister, Tony Kouzarides
Jul 23, 2004·Current Biology : CB·Craig L Peterson, Marc-André Laniel
Sep 25, 2004·Genes, Chromosomes & Cancer·Yuri N KobzevJanet D Rowley
Oct 7, 2004·Trends in Molecular Medicine·Jay L Hess
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William J Schouler MillerRosalie M Uht
Dec 2, 2005·Genes & Development·Athar Ansari, Michael Hampsey
Dec 27, 2005·Carcinogenesis·Craig G MoneypennyEvan P Gallagher
Apr 11, 2006·Reproductive Biology and Endocrinology : RB&E·Ann E Drummond
Apr 11, 2006·The Journal of Biological Chemistry·Rigen MoYi-Jun Zhu
Apr 25, 2006·Endocrine Reviews·Gaurang S Daftary, Hugh S Taylor
May 3, 2006·Cancer Research·Koen M A DreijerinkH Th Marc Timmers
Aug 1, 2006·Endocrine Reviews·Ulrich OhnemusRalf Paus
Aug 1, 2006·Nature Structural & Molecular Biology·Yali DouRobert G Roeder
Oct 18, 2006·Genes & Development·Robert J Sims, Danny Reinberg
Dec 16, 2006·ACS Chemical Biology·Brendan D Crawford, Jay L Hess
Mar 8, 2007·Nature Reviews. Molecular Cell Biology·Robert J Klose, Yi Zhang
Sep 7, 2007·Molecular Cell·Badri Nath Singh, Michael Hampsey
Dec 18, 2007·Biochimica Et Biophysica Acta·Khairul I AnsariSubhrangsu S Mandal
Jan 9, 2008·Journal of Inorganic Biochemistry·Getachew A Woldemariam, Subhrangsu S Mandal
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeongkyung LeeJae W Lee
Feb 20, 2009·Organic & Biomolecular Chemistry·Khairul I AnsariSubhrangsu S Mandal
Mar 7, 2009·Leukemia Research·Sabine SchnyderAndrew T Vaughan
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Khairul I AnsariSubhrangsu S Mandal
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeongkyung LeeJae W Lee

❮ Previous
Next ❯

Citations

Nov 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Kalypso KarastergiouSteven R Smith
Feb 19, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Arunoday BhanSubhrangsu S Mandal
Nov 30, 2013·European Archives of Psychiatry and Clinical Neuroscience·C SellmannF Matthäus
Feb 5, 2013·Journal of Molecular Biology·Arunoday BhanSubhrangsu S Mandal
Oct 1, 2011·Molecular and Cellular Endocrinology·Antje Stratmann, Bernard Haendler
Aug 26, 2015·Cellular and Molecular Life Sciences : CMLS·Hunain AlamMin Gyu Lee
Jul 26, 2015·Biochimica Et Biophysica Acta·Arunoday Bhan, Subhrangsu S Mandal
May 3, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M ArnaudD Geneviève
Feb 1, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Eric HervouetRégis Delage-Mourroux
Feb 25, 2011·Journal of Proteome Research·Martin J PfeifferMichele Boiani
Mar 29, 2014·ChemMedChem·Arunoday Bhan, Subhrangsu S Mandal
Jul 21, 2017·Cell Death & Disease·Changlin ZhangWuguo Deng
Mar 20, 2010·The FEBS Journal·Khairul I Ansari, Subhrangsu S Mandal
Feb 21, 2019·British Journal of Cancer·Michael J G MilevskiyMelissa A Brown
Jun 12, 2013·International Journal of Oncology·Doralina do Amaral RabelloFabio Pittella Silva
Mar 28, 2017·Epigenetics & Chromatin·Arnab NayakStefan Müller
Jun 2, 2021·Gene·Ajay KumarAnil Mukund Limaye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.