PMID: 9174630May 1, 1997Paper

Mixed medullary-follicular carcinoma of the thyroid. A morphological, immunohistochemical and in situ hybridization analysis of 11 cases

Virchows Archiv : an International Journal of Pathology
M PapottiR V Lloyd

Abstract

Mixed medullary-follicular carcinomas (MMFC) of the thyroid are rare tumours showing the morphological and immunochemical properties of both parafollicular and follicular cell lineages. Their recognition is based on a classical WHO definition, although several other patterns have been described in recent years. We investigated 11 cases of MMFC by immunohistochemistry and in situ hybridization (ISH) to analyse the structural features, the immunophenotypic profile and the calcitonin (CT) and thyroglobulin (TG) gene expression of the neoplasm. Histologically, 10 cases had mixed parafollicular and follicular cell populations in the primary tumour and 1 only in the lymph node metastasis. All cases were immunoreactive for CT (in medullary areas) and TG (in follicular areas and also in the solid component of 8/11 cases). These findings were confirmed by ISH analysis. Combined ISH and immunostaining showed that most cases had separate CT and TG gene expression, although rare cells with concurrent CT and TG gene expression were identified in 2 tumours. We conclude that (a) MMFC display heterogeneous morphological patterns and are a special type of thyroid tumour undergoing divergent differentiation; (b) in MMFC, CT and TG genes are gene...Continue Reading

Citations

Apr 8, 2004·Clinical Nuclear Medicine·Parul BhatnagarRavi Kashyap
Aug 4, 2001·International Journal of Surgical Pathology·J Rosai
Jan 9, 2019·Cell and Tissue Research·Yoko Kameda
Jul 8, 2020·Endocrine Pathology·José Manuel Cameselle-TeijeiroManuel Sobrinho-Simões
Jun 25, 2010·Advances in Anatomic Pathology·Peter M Sadow, Jennifer L Hunt
Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Marco VolanteMauro Papotti
Sep 5, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A RíosP Parrilla
Mar 5, 2009·Head & Neck·Charlette NangueSnezana Andrejevic-Blant
Jun 16, 2011·Internal Medicine·Ikuko UekiAtsushi Kawakami
Nov 30, 2013·Case Reports in Endocrinology·Maasumeh TohidiIraj Nabipour
Feb 7, 2018·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Ewa ChmielikBarbara Jarzab
Feb 3, 2004·Diagnostic Cytopathology·Rafael Luboshitzky, Muralee Dharan
Sep 12, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·P A BejaranoP W Biddinger
Mar 3, 2001·Journal of Endocrinological Investigation·F OrlandiS Filetti
Jul 15, 2017·Virchows Archiv : an International Journal of Pathology·Claudio De VitoAlberto Quaglia
Mar 7, 2021·International Journal of Molecular Sciences·Jinwei HuXiangpeng Yuan
Nov 7, 1999·The American Journal of Pathology·X Matias-Guiu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.