Mixed model approaches for the identification of QTLs within a maize hybrid breeding program.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Fred van EeuwijkMark Cooper

Abstract

Two outlines for mixed model based approaches to quantitative trait locus (QTL) mapping in existing maize hybrid selection programs are presented: a restricted maximum likelihood (REML) and a Bayesian Markov Chain Monte Carlo (MCMC) approach. The methods use the in-silico-mapping procedure developed by Parisseaux and Bernardo (2004) as a starting point. The original single-point approach is extended to a multi-point approach that facilitates interval mapping procedures. For computational and conceptual reasons, we partition the full set of relationships from founders to parents of hybrids into two types of relations by defining so-called intermediate founders. QTL effects are defined in terms of those intermediate founders. Marker based identity by descent relationships between intermediate founders define structuring matrices for the QTL effects that change along the genome. The dimension of the vector of QTL effects is reduced by the fact that there are fewer intermediate founders than parents. Furthermore, additional reduction in the number of QTL effects follows from the identification of founder groups by various algorithms. As a result, we obtain a powerful mixed model based statistical framework to identify QTLs in genet...Continue Reading

References

Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E S Lander, P Green
Oct 27, 1997·American Journal of Human Genetics·S C Heath
Apr 6, 2001·Genetics·T H MeuwissenM E Goddard
Jun 8, 2002·Journal of the American Academy of Nurse Practitioners·Kathryn R Puskar, Lisa Bernardo
Feb 13, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·M. BinkC. Jansen
Jul 23, 2003·Genetical Research·Jean-Luc Jannink, Xiao-Lin Wu
May 20, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·B Parisseaux, R Bernardo
Mar 9, 2005·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·J YuR Bernardo
Aug 10, 2006·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·T A SchragM Frisch
Dec 3, 2008·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias A SchragMatthias Frisch
Dec 17, 2008·Nature·Magnus Nordborg, Detlef Weigel
Apr 14, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Andrea Michaela BauerM J Sillanpää
Nov 26, 2009·Biometrical Journal. Biometrische Zeitschrift·An CreemersMichael G Kenward

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Citations

Jan 10, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Marco C A M BinkOscar S Smith
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xueqing HuangFred A van Eeuwijk
Nov 3, 2010·Journal of Experimental Botany·Carlos D MessinaMark Cooper
Apr 22, 2010·Genetics·Cajo J F ter BraakMarco C A M Bink
Nov 13, 2013·Journal of Experimental Botany·Mei GuoCarl R Simmons
Mar 23, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Marcio BalestreJúlio Sílvio de Sousa Bueno Filho
Mar 5, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Marcos MalosettiJosé-Luis Molina-Cano
May 23, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias Würschum
Aug 14, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jon M MassmanRex Bernardo
Mar 26, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jack ChristopherGraeme Hammer
Oct 17, 2015·BMC Genomics·Sébastien TisnéBenoît Cochard
Mar 7, 2014·Journal of Experimental Botany·Mark CooperCarlos Messina
Apr 13, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Rocío Acosta-PechPaulino Pérez-Rodríguez
Feb 28, 2020·Open Life Sciences·Agnieszka TomkowiakPrzemysław Łukasz Kowalczewski

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Software Mentioned

REML
[UNK]
MAS

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