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Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

bioRxiv

Sep 4, 2014

Tristan J HayeckAlkes L. Price

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Abstract

We introduce a Liability Threshold Mixed Linear Model (LTMLM) association statistic for ascertained case-control studies that increases power vs. existing mixed model methods, with a well-controlled false-positive rate. Recent work has shown that existing mixed model methods suffer a lo...read more

Mentioned in this Paper

Genetic Activator
Regression Analysis
Sclerosis
Dorsal
MS gene
Simulation
Single Nucleotide Polymorphism
Case Control
Hereditary Liability to Pressure Palsies
Posterior Pituitary Disease
4
1
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  • Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

    bioRxiv

    Sep 4, 2014

    Tristan J HayeckAlkes L. Price

    PMID: 990008755

    DOI: 10.1101/008755

    Abstract

    We introduce a Liability Threshold Mixed Linear Model (LTMLM) association statistic for ascertained case-control studies that increases power vs. existing mixed model methods, with a well-controlled false-positive rate. Recent work has shown that existing mixed model methods suffer a lo...read more

    Mentioned in this Paper

    Genetic Activator
    Regression Analysis
    Sclerosis
    Dorsal
    MS gene
    4
    1

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