Mixed mold pulmonary infections in haematological cancer patients in a tertiary care cancer centre

Mycoses
Eleni E MagiraDimitrios P Kontoyiannis

Abstract

There is a paucity of data regarding mixed mold pulmonary infections (MMPIs) in patients with haematological malignancies with or without haematopoietic stem cell transplantation (HSCT). We retrospectively studied 27 such patients (2005-2015) and compared them to patients with invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus. Factors associated with the diagnosis of MMPIs were significant corticosteroid use [20 (74%) vs 6 (22%), P < 0.001], sputum as the source specimen [13 (48%) vs 3 (11%), P = 0.003], younger age (median age: 58 vs 66 years, P = 0.006), and male sex [22 (81%) vs 13 (48%), P = 0.01]. Haematological cancers other than acute myeloid leukaemia (AML)/myelodysplastic syndromes (MDS) were less common in MMPIs than in IPA patients [AML/MDS: 6 (22%) vs 14 (52%), P = 0.04]. Only significant corticosteroid use [95% CI (2.7-42.7), P < 0.001], and sputum as the source specimen [95% (1.6-41.6), P = 0.012] were statistically significant as independently associated with increased risk of MMPIs diagnosis in multivariate analysis. Total mortality rate at day 42 postdiagnosis was comparable in both groups.

References

Feb 1, 1996·The American Journal of Medicine·J A Horvath, S Dummer
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Jan 7, 1998·Journal of the American Academy of Dermatology·P VasiloudesW L Weston
Mar 7, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kieren A MarrLawrence Corey
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Feb 13, 2013·Clinical Drug Investigation·Rui BergantimJose Eduardo Guimarães
Aug 5, 2014·Mycopathologia·Setareh DavoudiDimitrios P Kontoyiannis

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Citations

May 28, 2020·Mycoses·Amalia AnastasopoulouDimitrios P Kontoyiannis
Sep 11, 2020·Case Reports in Infectious Diseases·Maria Tsikala-VafeaDimitrios Farmakiotis

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