Mixed (neutrophil-rich) interstitial pneumonitis in biopsy specimens of lung allografts: a clinicopathologic evaluation

Chest
J W McDonaldE M Brunt

Abstract

Mixed interstitial pneumonitis (MIP), defined herein as a diffuse neutrophil-rich inflammatory infiltrate within the interstitial tissues, is an uncommon finding that is not a standard manifestation of acute or chronic rejection. This study examines the clinical significance of MIP in lung allograft recipients at St. Louis University Hospital. We retrospectively reviewed surgical pathology reports from a selected 50-month period, and identified MIP reported in 13 transbronchial biopsy specimens in lung transplant recipients, representing 4.7% of all lung allograft biopsy specimens seen during this 4-year period. Biopsy specimens with MIP were examined to confirm the presence of a neutrophil-rich interstitial infiltrate and other associated histopathologic findings. The culture results, cytopathologic findings, and clinical charts of the affected patients were also reviewed. The detection of MIP at some point in a patient's posttransplant course was found to be associated with a significantly shorter (p < 0.01) survival, when compared to lung allograft recipients who did not show this finding. A total of seven lung allograft recipients (23% of total) showed MIP at some point in their posttransplant course. Four of the seven (57%...Continue Reading

References

Sep 1, 1992·The American Journal of Surgical Pathology·S A YousemB P Griffith
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Jun 1, 1986·Transplantation·J S DummerM Ho
Dec 1, 1994·The American Journal of Surgical Pathology·N P OhoriS A Yousem

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.