PMID: 7021331Jun 1, 1981Paper

Mixed pancreatic apudoma with symptoms of excess vasoactive intestinal polypeptide and insulin: improvement of diarrhoea with metoclopramide

Gut
R G LongS R Bloom

Abstract

A female patient is described with a single pancreatic tumour producing vasoactive intestinal polypeptide (VIP), insulin, and pancreatic polypeptide. The initial presentation was with diarrhoea and hypokalaemia and a raised plasma VIP was demonstrated. Her symptoms improved with metoclopramide administration and absolute concentrations of 28 aminoacid (peak IV) VIP were found to have fallen. She then developed hypoglycaemia with hyperinsulinism. All symptoms resolved after surgical excision. This case emphasises the potential of these tumours to contain more than one endocrine cell type synthesising different biologically active peptides.

References

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Citations

Jan 1, 1988·Digestive Diseases and Sciences·H HagegeJ P Etienne
Apr 1, 1985·World Journal of Surgery·P DurningR B Welbourn
Jan 1, 1989·Pharmacology & Therapeutics·D WynickS R Bloom
Nov 1, 1988·Baillière's Clinical Endocrinology and Metabolism·R V Thakker, B A Ponder
Jan 3, 1985·The New England Journal of Medicine·P N MatonR T Jensen
May 1, 1983·Postgraduate Medical Journal·R G Long
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J V Anderson, S R Bloom
Dec 1, 1996·Baillière's Clinical Gastroenterology·S K ParkT M O'Dorisio
Sep 1, 1987·Seminars in Oncology·H S Mekhjian, T M O'Dorisio
Jan 1, 1988·Annals of the New York Academy of Sciences·S R BloomJ M Polak
Apr 1, 1987·British Journal of Urology·E A KielyG Williams
Aug 9, 2016·Annals of Surgery·William Y CheyEdwin Christopher Ellison
Aug 27, 2005·Acta Oncologica·Marie-Louise Fjällskog, Eva Tiensuu Janson
May 29, 1987·The American Journal of Medicine·G J Krejs
Jan 1, 1984·Critical Reviews in Oncology/hematology·C J LipsC B Lamers

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