Mixed strain infections and strain-specific protective immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi in mice.

Infection and Immunity
Sandra CheesmanRichard Carter

Abstract

Important to malaria vaccine design is the phenomenon of "strain-specific" immunity. Using an accurate and sensitive assay of parasite genotype, real-time quantitative PCR, we have investigated protective immunity against mixed infections of genetically distinct cloned "strains" of the rodent malaria parasite Plasmodium chabaudi chabaudi in mice. Four strains of P. c. chabaudi, AS, AJ, AQ, and CB, were studied. One round of blood infection and drug cure with a single strain resulted in a partial reduction in parasitemia, compared with levels for naïve mice, in challenge infections with mixed inocula of the immunizing (homologous) strain and a heterologous strain. In all cases, the numbers of blood-stage parasites of each genotype were reduced to similar degrees. After a second, homologous round of infection and drug cure followed by challenge with homologous and heterologous strains, the parasitemias were reduced even further. In these circumstances, moreover, the homologous strain was reduced much faster than the heterologous strain in all of the combinations tested. That the immunity induced by a single infection did not show "strain specificity," while the immunity following a second, homologous infection did, suggests that ...Continue Reading

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Citations

Feb 23, 2008·Proceedings. Biological Sciences·Victoria C BarclayAndrew F Read
Feb 24, 2012·Proceedings. Biological Sciences·Vincent StaszewskiEmma J A Cunningham
Dec 2, 2010·The American Journal of Tropical Medicine and Hygiene·Fadile Yildiz ZeyrekKazuyuki Tanabe
Nov 22, 2011·Trends in Parasitology·Robin StephensTracey J Lamb
Aug 21, 2007·Molecular and Biochemical Parasitology·Kazuyuki TanabeHirohisa Kishino
Jan 16, 2007·International Journal for Parasitology·Richard CarterSandra Cheesman
Jun 11, 2008·Evolution; International Journal of Organic Evolution·Katrina GrechAndrew F Read
Jan 6, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sandra CheesmanRichard Carter
Sep 23, 2008·Vaccine·Victoria C BarclayAndrew F Read
Dec 25, 2012·Molecular and Biochemical Parasitology·Elizabeth A Thiele, Dennis J Minchella
Oct 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henrique Borges da SilvaMaria Regina D'Império Lima
Jan 12, 2021·Expert Review of Vaccines·Reshma J NevagiDanielle I Stanisic
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Xin-Zhuan SuDeirdre A Joy
May 24, 2021·Molecular and Biochemical Parasitology·Petra Schneider, Sarah E Reece

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