Mixed Ventilatory Defects in Pulmonary Sarcoidosis: Prevalence and Clinical Features.

Chest
Vasileios KouranosAthol U Wells

Abstract

In cohort studies of pulmonary sarcoidosis, abnormal ventilatory patterns have generally been subdivided into restrictive and obstructive defects. Mixed ventilatory defects have largely been overlooked in pulmonary sarcoidosis, as total lung capacity has seldom been taken into account in historical series. This study evaluated the prevalence of mixed disease in pulmonary sarcoidosis and its clinical associations. In patients with pulmonary sarcoidosis (N = 1,110), mixed defects were defined according to American Thoracic Society/European Respiratory Society criteria. Clinical data, pulmonary function variables, and vital status were abstracted from clinical records. Chest radiographs were evaluated independently by two experienced radiologists. The prevalence of a mixed ventilatory defect was 10.4% in the whole cohort, rising to 25.9% in patients with airflow obstruction. Compared with isolated airflow obstruction, mixed defects were associated with lower diffusing lung capacity for carbon monoxide levels (50.7 ± 16.3 vs 70.8 ± 18.1; P < .0001), a higher prevalence of chest radiographic stage IV disease (63.5% vs 38.3%; P < .0001), and higher mortality (hazard ratio, 2.36; 95% CI, 1.34-4.15; P = .003). These findings were repro...Continue Reading

Citations

May 12, 2021·Journal of Biomechanical Engineering·Caymen NovakSamir Ghadiali
Dec 5, 2021·BMC Pulmonary Medicine·Björn Christian FryeJonas Christian Schupp

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