Mixing biomimetic heterodimers of nucleopeptides to generate biocompatible and biostable supramolecular hydrogels

Angewandte Chemie
Dan YuanBing Xu

Abstract

As a new class of biomaterials, most supramolecular hydrogels formed by small peptides require the attachment of long alkyl chains, multiple aromatic groups, or strong electrostatic interactions. Based on the fact that the most abundant protein assemblies in nature are dimeric, we select short peptide sequences from the interface of a heterodimer of proteins with known crystal structure to conjugate with nucleobases to form nucleopeptides. Being driven mainly by hydrogen bonds, the nucleopeptides self-assemble to form nanofibers, which results in supramolecular hydrogels upon simple mixing of two distinct nucleopeptides in water. Moreover, besides being biocompatible to mammalian cells, the heterodimer of the nucleopeptides exhibit excellent proteolytic resistance against proteinase K. This work illustrates a new and rational approach to create soft biomaterials by a supramolecular hydrogelation triggered by mixing heterodimeric nucleopeptides.

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S ZhangA Rich
Aug 15, 1996·Nature·J H Morais CabralR C Liddington
Aug 11, 1998·Nature Genetics·V A LettsW N Frankel
Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·D S Goodsell, A J Olson
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·J KisidayA J Grodzinsky
Apr 24, 2003·Science's STKE : Signal Transduction Knowledge Environment·Claire NourryJean-Paul Borg
Jun 4, 1962·Biochemical and Biophysical Research Communications·K SCHERRER, J E DARNELL
Mar 11, 2004·Chemical Reviews·Lara A Estroff, Andrew D Hamilton
Dec 15, 2005·Angewandte Chemie·Takashi KatoKenji Kishimoto
Feb 24, 2007·Journal of the American Chemical Society·Nori YamaguchiKristi L Kiick
Oct 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Sangita RoyPrasanta Kumar Das
Mar 14, 2008·Journal of the American Chemical Society·Radhika P NagarkarJoel P Schneider
Aug 30, 2008·Accounts of Chemical Research·Liam C Palmer, Samuel I Stupp
Nov 6, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·G N RovielloE Benedetti
Mar 24, 2010·Journal of the American Chemical Society·Eleanor K JohnsonPetra J Cameron
Jun 1, 2010·Angewandte Chemie·Job BoekhovenJan H van Esch
Sep 24, 2010·Journal of the American Chemical Society·Tijana Z GroveLynne Regan
Jan 1, 1946·The Journal of Pathology and Bacteriology·M HAINES
Jan 21, 2011·Journal of the American Chemical Society·Masato IkedaItaru Hamachi
Aug 26, 2011·Journal of the American Chemical Society·Katelyn J NagyJoel P Schneider
Sep 29, 2011·Angewandte Chemie·Xinming LiBing Xu
Nov 10, 2011·Journal of the American Chemical Society·Julie A ZornJames A Wells
Nov 15, 2011·Chemical Communications : Chem Comm·John B Matson, Samuel I Stupp
Dec 17, 2011·Journal of the American Chemical Society·Fei XuVikas Nanda
Dec 18, 2012·Journal of the American Chemical Society·Wenting ZhengZhimou Yang
Feb 6, 2013·Journal of the American Chemical Society·Andrew G CheethamHonggang Cui
Mar 14, 2013·Journal of the American Chemical Society·Matthieu SainlosBarbara Imperiali
Apr 26, 2013·Biopolymers·Katherine JoynerY Bruce Yu
Oct 24, 2013·Journal of the American Chemical Society·Sisir DebnathRein V Ulijn
Mar 13, 2014·Angewandte Chemie·Alexandre G L OliveJan H van Esch
May 14, 2014·Angewandte Chemie·Yi KuangBing Xu

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Citations

Aug 4, 2015·Journal of the American Chemical Society·Dan YuanBing Xu
Mar 3, 2017·ACS Applied Materials & Interfaces·Jie ZhanZhimou Yang
Jan 24, 2017·Advanced Materials·Xiao-Qiu Dou, Chuan-Liang Feng
May 18, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Annada RajbhandaryBradley L Nilsson
May 10, 2017·Angewandte Chemie·Huaimin WangBing Xu
Jun 15, 2017·ACS Applied Materials & Interfaces·Ashok Nuthanakanti, Seergazhi G Srivatsan
Oct 13, 2015·Organic & Biomolecular Chemistry·Wei WangYan Zhang
May 3, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan YuanBing Xu
Jun 16, 2016·Chemical Society Reviews·Luis M De Leon RodriguezMargaret A Brimble
Aug 15, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan Yuan, Bing Xu
Nov 18, 2017·Interface Focus·Xuewen DuBing Xu
Mar 25, 2019·Angewandte Chemie·Huaimin WangBing Xu
Oct 1, 2019·Chemistry : a European Journal·Concetta AvitabileAlessandra Romanelli
Jul 1, 2020·Chemical Communications : Chem Comm·Redouane BeniazzaJean-Marc Vincent
Oct 11, 2017·Bioengineering & Translational Medicine·Yi LiHonggang Cui
Jul 28, 2015·Chemistry, an Asian Journal·Lin ChenHe Tian
Feb 19, 2016·Chembiochem : a European Journal of Chemical Biology·Huiling JiangYonggang Ke
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiahong JinLi Ren
Oct 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lijing TengLi Ren
Jan 1, 2017·ChemPlusChem·Shivaprasad Manchineella, T Govindaraju
Feb 27, 2020·Chemical Reviews·Moran Frenkel-PinterLuke J Leman
Aug 2, 2017·Analytical Biochemistry·Peter WorthingtonSigrid A Langhans
Mar 21, 2017·Biomaterials·Jie ZhouBing Xu
Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pasqualina Liana ScognamiglioGiovanni Nicola Roviello

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