Mixing bone graft with OP-1 does not improve cup or stem fixation in revision surgery of the hip: 5-year follow-up of 10 acetabular and 11 femoral study cases and 40 control cases

Acta Orthopaedica
Johan KärrholmReza Razaznejad

Abstract

Bone morphogenetic proteins (BMPs) have the potential to improve incorporation of allograft bone in revision surgery. This could result in improved fixation and graft incorporation. We evaluated the effect of mixing OP-1 (BMP-7) with morselized allograft in hip revisions. In a case-control study, 20 acetabular revisions (10 in the study group, 10 controls) and 41 femoral revisions (11 in study group, 30 controls) were done using impaction allografting. The migration of the cups and stems was studied with radiostereometric analysis (RSA) for up to 5 years. Changes of bone mineral density around the femoral component were measured with dual energy X-ray adsorptiometry for 2 years. Bone remodeling and the extent of radiolucent lines were evaluated on conventional radiographs after 5 years. The clinical results were documented using Harris hip score. In the cup study, there was no significant difference in implant migration between the study and control groups. 4 sockets in the study group were classified as radiographically loose after 5 years and 2 of them were revised after 5 years. After 2 years, the stems in the study group showed slightly increased posterior tilt (0.3 degrees , p = 0.03). 1 stem in the study group loosened an...Continue Reading

References

Apr 1, 1998·Archives of Orthopaedic and Trauma Surgery·G Ullmark, L Linder
Nov 20, 2001·The Journal of Bone and Joint Surgery. American Volume·K L Wong, G R Williams
Dec 14, 2001·The Journal of Arthroplasty·S D CookJ P Carvajal
Dec 19, 2001·Journal of Biomechanics·Niclas BörlinJohan Kärrholm
Feb 16, 2002·The Journal of Arthroplasty·G Ullmark, K J Obrant
Apr 4, 2002·Acta Orthopaedica Scandinavica·Thomas B JensenKjeld Søballe
Aug 15, 2002·The Journal of Bone and Joint Surgery. American Volume·Ewald OrnsteinMartin Sundberg
Aug 20, 2003·The Journal of Bone and Joint Surgery. American Volume·Thomas A Einhorn
Oct 3, 2003·Acta Orthopaedica Scandinavica·Charlotte JeppssonPer Aspenberg
Dec 6, 2003·The Journal of Arthroplasty·Peter HultmarkJohan Kärrholm
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jörgen Astrand, Per Aspenberg
Oct 27, 2004·Journal of Biomedical Materials Research. Part a·Kjeld SøballeJoan E Bechtold

❮ Previous
Next ❯

Citations

Oct 27, 2009·International Orthopaedics·Thomas Bo JensenK Søballe
Sep 26, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·M VillanuevaM P G Böstrom
Sep 23, 2008·Injury·Nikolaos K KanakarisPeter V Giannoudis
Jan 18, 2008·International Orthopaedics·Gerjon HanninkPieter Buma
Mar 12, 2008·Expert Review of Medical Devices·James B StiehlMichael A Mont
May 1, 2007·Injury·Eleftherios TsiridisPeter V Giannoudis
Aug 1, 2013·Journal of Orthopaedic Surgery and Research·Vasilis ZampelisJian-Sheng Wang
Nov 4, 2017·International Orthopaedics·Scott R NodzoSridhar Rachala
Oct 5, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rasmus CleemannJorgen Baas
May 22, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Pieter BumaB Willem Schreurs
Apr 12, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anna Kajsa HardingMagnus Tägil
Mar 12, 2009·Journal of Biomechanical Engineering·Frank SeehausChristof Hurschler
Mar 10, 2010·Journal of Orthopaedic Trauma·Peter V Giannoudis, Haralampos T Dinopoulos
Jun 6, 2015·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Ena ColoBerend Willem Schreurs
Sep 1, 2017·JBJS Reviews·Ameer ElbulukRichard Iorio
Feb 6, 2019·Frontiers in Bioengineering and Biotechnology·Sophie Le CannHanna Isaksson
Nov 5, 2013·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Tuuli M SaariJohan N Kärrholm
Jul 11, 2007·Clinical Orthopaedics and Related Research·Thomas JakobsenKjeld Søballe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Margaret A McGeeCarol Toth
The Journal of Bone and Joint Surgery. American Volume
Alan L JonesBMP-2 Evaluation in Surgery for Tibial Trauma-Allgraft (BESTT-ALL) Study Group
The Journal of Bone and Joint Surgery. American Volume
B Willem SchreursJean W M Gardeniers
© 2021 Meta ULC. All rights reserved