Mixing rapid-acting insulin analogues with insulin glargine in children with type 1 diabetes mellitus

The Journal of Pediatrics
Rosanna Fiallo-ScharerH Peter Chase

Abstract

To determine whether mixing insulin glargine (IG) with a rapid-acting insulin (RAI) analogue in the same syringe had any deleterious effects on glycemic control in children with type 1 diabetes mellitus. Data from 55 children mixing the IG with a RAI analogue was collected for 6 months before and 6 months after the insulin mixing began. Data from a control group of 55 children not mixing the insulins was collected at similar intervals. Parameters evaluated included hemoglobin A1c (HbA1c) values, number of non-severe and severe hypoglycemic events, number of diabetic ketoacidosis (DKA) events, and blood glucose distribution patterns. After 6 months of study, HbA1c values were equivalent for the control and test groups (8.54+/-1.14 vs 8.61+/-1.14, respectively; P=1.0000). Percentages of blood glucose values in, above, and below the target range did not vary significantly in the groups. There were no significant differences in the groups in the occurrence of non-severe or severe hypoglycemic events or of DKA events. There were no significant differences in glycemic control between children who mixed IG in the same syringe with a RAI analogue compared with children who took separate injections.

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Oct 27, 2004·Diabetes Care·Walid KaplanRubina A Heptulla
Aug 20, 2005·Pediatric Diabetes·Brenner DixonSatish K Garg

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Citations

Apr 12, 2007·Current Diabetes Reports·Jamie R Wood, Lori M B Laffel
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Stanislav GoykhmanMarc Rendell
Jan 29, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·L Tapia Ceballos
Sep 17, 2009·Pediatric Diabetes·Hans-Jacob BangstadRagnar Hanas
Oct 25, 2007·Pediatric Diabetes·Andrea K SteckRosanna Fiallo-Scharer
Feb 9, 2012·International Journal of Clinical Practice. Supplement·Shlomit Shalitin, H Peter Chase
Mar 1, 2012·Diabetes Care·Eda CengizStuart A Weinzimer

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