PMID: 9004395Jan 15, 1997Paper

Mixture models for the joint distribution of repeated measures and event times

Statistics in Medicine
Joseph W Hogan, N M Laird

Abstract

Many long-term clinical trials collect both a vector of repeated measurements and an event time on each subject; often, the two outcomes are dependent. One example is the use of surrogate markers to predict disease onset or survival. Another is longitudinal trials which have outcome-related dropout. We describe a mixture model for the joint distribution which accommodates incomplete repeated measures and right-censored event times, and provide methods for full maximum likelihood estimation. The methods are illustrated through analysis of data from a clinical trial for a new schizophrenia therapy; in the trial, dropout time is closely related to outcome, and the dropout process differs between treatments. The parameter estimates from the model are used to make a treatment comparison after adjusting for the effects of dropout. An added benefit of the analysis is that it permits using the repeated measures to increase efficiency of estimates of the event time distribution.

Citations

Mar 14, 2002·Biometrics·M Pourahmadi, M J Daniels
Apr 25, 2008·BMC Public Health·Ramón A Durazo-ArvizuTerrence Forrester
Sep 14, 2013·Journal of the American Pharmacists Association : JAPhA·Bonnie L SvarstadDale A Wilson
Dec 24, 2002·Biometrics·Jolene Birmingham, Garrett M Fitzmaurice
Dec 24, 2002·Biometrics·Lurdes Y T InoueDonald A Berry
Dec 1, 2010·Heart & Lung : the Journal of Critical Care·Patricia Flatley BrennanBillie Sturgeon
Sep 2, 2004·Biometrics·Lei LiuXuelin Huang
Jul 10, 2008·Statistics in Medicine·Keunbaik Lee, Michael J Daniels
Dec 17, 2008·Statistics in Medicine·Niko A KacirotiStevo Julius
Mar 21, 2008·Statistics in Medicine·Li Su, Joseph W Hogan
May 19, 2011·Statistics in Medicine·Liddy M ChenHaitao Chu
Feb 22, 2012·Statistics in Medicine·Colleen M SitlaniTor D Tosteson
May 6, 2011·Statistics in Medicine·Rinke H Klein EntinkArdo van den Hout
May 23, 2014·Statistics in Medicine·Victoria Liublinska, Donald B Rubin
Dec 24, 2009·Biometrical Journal. Biometrische Zeitschrift·M Tariqul HasanRenjun Ma
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Aug 5, 2003·Statistics in Medicine·Hakan Demirtas, Joseph L Schafer
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May 20, 2006·Biometrical Journal. Biometrische Zeitschrift·Molin Wang, Garrett M Fitzmaurice
Jan 26, 2006·Statistics in Medicine·Huiling Li, Daniel F Heitjan
Dec 15, 2007·Biometrics·Keunbaik Lee, Michael J Daniels

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