Abstract
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite. Treatment of the infection induced by this parasite is not straightforward due to the toxic side effects of the available drugs. Vaccine development could be a solution to this problem. In the present study, T.gondii Lysate Antigen (TLA), as a model vaccine, in combination with the Alum-NLT (Aluminum phosphate-Naltrexone) and Alum-NLX (Aluminum phosphate-Naloxone) were evaluated for immunization BALB/c. 147 female BALB/c mice which were divided into seven groups of 21, were allocated to immunization experiments. The first group was selected as the negative control group, followed by the second, third, fourth, fifth, sixth and seventh groups which were immunized with Vac, Vac-Alum, Vac-NLX, Vac-NLT, Vac-Alum-NLX, Vac-Alum-NLT, respectively. Ten days after the final immunization, mice in all groups were divided into three groups for evaluating cellular immune responses, measuring the delayed-type hypersensitivity responses (DTHs) and evaluating survival. The DTH and cellular immune responses showed that in mice immunized with the TLA vaccine combined with the Alum-NLT mixture, the efficacy improved by increasing the production of Interleukin-5(IL-5) and Interfer...Continue Reading
References
Jan 1, 1992·Vaccine·S B DillonN Hanna
Apr 22, 1988·Science·Y SuzukiJ S Remington
Dec 1, 1970·The Journal of Infectious Diseases·J K Frenkel
Mar 21, 1998·Journal of Cutaneous Pathology·C L EganG F Murphy
Jul 31, 1998·Vaccine·E PetersenJ Spenter
Sep 16, 1998·Clinical and Experimental Immunology·P SacerdoteA E Panerai
Apr 2, 1999·Parasite Immunology·V L Pereira-ChioccolaM M Rodrigues
Feb 13, 2001·Infection and Immunity·M UlanovaL A Hanson
Apr 16, 2003·Veterinary Parasitology·Ahmad DaryaniAbdolhossein Dalimi
Aug 23, 2003·Infection and Immunity·Isabelle Dimier-PoissonDaniel Bout
Jul 10, 2004·Clinical and Diagnostic Laboratory Immunology·Valentina MartinSergio O Angel
Nov 29, 2005·Nature Immunology·Qizhi TangJeffrey A Bluestone
Sep 23, 2006·Vector Borne and Zoonotic Diseases·B G MeerburgM F Mul
May 17, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Carlos José Dornas Gonçalves BarbosaMario León Silva-Vergara
Aug 3, 2007·Microbial Pathogenesis·Abbas JamaliTaravat Bamdad
Aug 25, 2007·International Journal of Medical Microbiology : IJMM·Stefan ZimmermannKlaus Heeg
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jagadeesh BayryDavid F Tough
Jul 25, 2008·European Journal of Immunology·Ennio De GregorioRino Rappuoli
Aug 16, 2008·Journal of Pharmaceutical Sciences·Jennifer H Wilson-WelderBalaji Narasimhan
Jan 29, 2009·International Immunology·Abbas JamaliShahram Shahabi
May 12, 2009·Memórias do Instituto Oswaldo Cruz·Erik JongertEskild Petersen
Aug 25, 2009·British Dental Journal· Anon
Aug 27, 2009·International Immunopharmacology·Agheel Tabar Molla HassanSeyed Mahmoud Hashemi
Jan 13, 2010·Vaccine·Ali M HarandiUNKNOWN Working Group convened by EUROPRISE
Feb 16, 2010·Microbes and Infection·Nima Hosseini JazaniShahram Shahabi
Jan 14, 2012·Vaccine·Huaiyu ZhouShenyi He
Feb 22, 2012·Vaccine·Ebrahim MazloomiShahram Shahabi
Citations
Apr 18, 2013·PLoS Pathogens·Pádraig J RossKingston H G Mills
Jul 26, 2016·Frontiers in Microbiology·Alireza TahamtanVahid Salimi
Mar 11, 2011·Trends in Immunology·Md Hasan ZakiThirumala-Devi Kanneganti
Dec 20, 2017·Medical Microbiology and Immunology·Vahid SalimiTalat Mokhtari-Azad
Feb 23, 2019·Acta Parasitologica·Hakim AziziSamira Elikaee
Aug 4, 2020·Journal of Leukocyte Biology·Noelia Anahí CampraLaura Noelia Cariddi
Jun 27, 2020·The Journal of Pharmacology and Experimental Therapeutics·Michael D RaleighMarco Pravetoni
Mar 25, 2017·Future Microbiology·Céline DucournauIsabelle Dimier-Poisson
Dec 6, 2019·Peptides·Richard J Bodnar
Apr 3, 2021·International Journal for Parasitology·Sakineh PirahmadiAkram A Mehrizi