Mixtures of four organochlorines enhance human breast cancer cell proliferation

Environmental Health Perspectives
J PayneAndreas Kortenkamp

Abstract

In view of the large differences between the concentrations of estrogenic chemicals needed to elicit effects in in vitro assays and their levels in human tissues, it is hard to explain possible health risks in terms of exposure to individual compounds. Human populations, however, are exposed to mixtures of estrogenic and estrogen-like agents and it is necessary to consider the impact of combined effects. We assessed the combined effects of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2,2-trichloroethane (o,p'-DDT), 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), beta-hexachlorocyclohexane (beta-HCH), and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (p,p'-DDT) on the induction of cell proliferation in MCF-7 cells. All four compounds are persistent organochlorines that can be found in human tissues. We performed extensive concentration-response analyses with the single agents to predict the effects of two mixtures of all four compounds with different mixture ratios. We calculated the predictions by using the pharmacologically well-founded models of concentration addition and independent action and then tested them experimentally. o,p'-DDT, p,p'-DDE, beta-HCH, and p,p'-DDT acted together to produce proliferative effects in MC...Continue Reading

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Oct 1, 1988·Bulletin of Environmental Contamination and Toxicology·S BustosA N Tchernitchin
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y BerthoisB S Katzenellenbogen
Jun 7, 1985·Journal of Theoretical Biology·M C Berenbaum
Feb 1, 1995·Journal of the National Cancer Institute·P G TonioloB S Pasternack
Dec 17, 1994·Lancet·E DewaillyS Dodin
Oct 1, 1993·Environmental Health Perspectives·D L DavisH Anton-Culver
Apr 20, 1994·Journal of the National Cancer Institute·N KriegerN Orentreich
Jan 1, 1994·Environmental Health Perspectives·P FürstK Wilmers
Oct 1, 1995·Environmental Health Perspectives·A M SotoF O Serrano
Oct 1, 1995·Environmental Health Perspectives·J P Sumpter, S Jobling
Mar 6, 1996·Journal of the National Cancer Institute·F BerrinoG Secreto
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek
Feb 6, 1997·Nature·J AshbyJ P Sumpter
Jul 12, 1997·BMJ : British Medical Journal·P van't VeerF J Kok
Nov 5, 1997·The New England Journal of Medicine·D J HunterM S Wolff
Dec 10, 1997·Journal of the National Cancer Institute·N E Davidson, J D Yager
Nov 12, 1998·The Science of the Total Environment·A Kortenkamp, R Altenburger
May 7, 1999·Environmental Health Perspectives·H R AndersenA M Soto
Sep 24, 1999·The Science of the Total Environment·A Kortenkamp, R Altenburger
May 12, 2000·The Science of the Total Environment·J PayneA Kortenkamp

❮ Previous
Next ❯

Citations

Jan 11, 2002·International Journal of Occupational and Environmental Health·M Kishi, J Ladou
Jul 11, 2001·Environmental Health Perspectives·D AxelrodL A Jones
Feb 9, 2002·Environmental Health Perspectives·David O CarpenterDavid C Spink
Apr 6, 2004·Environmental Health Perspectives·Helen Tinwell, John Ashby
Sep 25, 2004·Environmental Health : a Global Access Science Source·Maureen R GwinnAinsley Weston
Jun 3, 2005·Environmental Health Perspectives·Jayne V BrianJohn P Sumpter
May 6, 2006·Environmental Health : a Global Access Science Source·Eva C Bonefeld-JorgensenJens Peter Bonde
Jul 13, 2006·Environmental Health Perspectives·Ida N DamgaardUNKNOWN Nordic Cryptorchidism Study Group
Jan 5, 2008·Environmental Health Perspectives·Tanja KrügerEva C Bonefeld-Jørgensen
Jan 5, 2008·Environmental Health Perspectives·Andreas Kortenkamp
Jan 5, 2008·Environmental Health Perspectives·Andreas KortenkampThomas Backhaus
Jan 5, 2008·Environmental Health Perspectives·Ana D CorreiaMaria A Reis-Henriques
Jan 5, 2008·Environmental Health Perspectives·Ulla HassAndreas Kortenkamp
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrew K HotchkissL Earl Gray
Jul 17, 2008·Environmental Health : a Global Access Science Source·Tanja KrügerEva C Bonefeld-Jorgensen
Mar 17, 2006·Breast Cancer Research and Treatment·Kristen S KulpL Michelle Bennett
Aug 17, 2010·Ecotoxicology·Hui ZhangHong-Er Tian
Jul 26, 2003·Food Additives and Contaminants·P LaierA M Vinggaard
May 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Elisabete SilvaAndreas Kortenkamp
Oct 28, 2009·Carcinogenesis·Philippe Irigaray, Dominique Belpomme
Sep 19, 2014·International Journal of Environmental Research and Public Health·Svenja RiekePhilip Marx-Stoelting
May 23, 2015·Oncology Reports·Lino Del PupMassimiliano Berretta
Dec 5, 2002·Environmental Toxicology and Chemistry·Tomoko KodaMasatoshi Morita
Nov 21, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Natsuko TakakuraLudovic Le Hégarat
Jun 5, 2012·Journal of Environmental Sciences (China)·Weiwei JiangSenthil Kumaran Satyanarayanan
Mar 9, 2010·Toxicology and Applied Pharmacology·Elisabete SilvaAndreas Kortenkamp
Apr 14, 2009·Toxicology and Applied Pharmacology·Gianpaolo RandoAdriana Maggi
Jan 27, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ramiro DipHanspeter Naegeli
Feb 26, 2008·Toxicology·Tanja KrügerEva C Bonefeld-Jørgensen
Nov 24, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P IrigarayD Belpomme
Jul 10, 2007·The Science of the Total Environment·Corine J HoutmanHans J C Klamer
May 1, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mariana F FernandezNicolas Olea
Mar 12, 2016·Environmental Science and Pollution Research International·Xiangyang WuLiuqing Yang
Sep 29, 2015·Environmental Pollution·Shuangying YuJonathan D Maul
Oct 4, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Tanja KrügerEva C Bonefeld-Jørgensen
Mar 19, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Juan P ArrebolaNicolás Olea
Oct 10, 2006·Toxicology and Applied Pharmacology·Petra Y Kunz, Karl Fent
Jun 4, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·James WattJennifer J Schlezinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
S N KolleB van Ravenzwaay
Environmental Health Perspectives
Ernie Hood
© 2021 Meta ULC. All rights reserved