MK-801 increases locomotor activity in a context-dependent manner in zebrafish

Behavioural Brain Research
Steven TranRobert Gerlai

Abstract

Zebrafish have become a popular animal model for behavioral neuroscience with an increasing number of studies examining the effects of pharmacological compounds targeting the brain. Exposure to MK-801, a non-competitive N-methyl-d-aspartate receptor antagonist has been shown to increase locomotor activity in zebrafish. However, others have failed to replicate this finding as several contradicting studies report no changes in locomotor activity following exposure to similar doses. In the current study we reconcile these behavioral reports by demonstrating that zebrafish do not exhibit changes in locomotor activity during exposure to non-sedative doses of MK-801. Interestingly, zebrafish do exhibit significant increases in locomotion if pre-treated with MK-801 followed by subsequent testing in a novel environment, which suggests the effects of MK-801 are context-dependent. In addition, we examine the potential role of the dopaminergic system in mediating MK-801's locomotor stimulant effect by quantifying the levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the brains of zebrafish following a 30 min exposure to 10 μM of MK-801 (the dose found to induce the largest increase in locomotor activity). Our...Continue Reading

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Jan 21, 2015·Zebrafish·Fabiano Peres MenezesRosane Souza Da Silva

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Citations

Feb 5, 2016·ACS Chemical Biology·Matthew N McCarrollDavid Kokel
Mar 10, 2016·Psychopharmacology·Steven TranRobert Gerlai
Feb 18, 2016·Psychopharmacology·Steven TranRobert Gerlai
Jul 12, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Francini FranscesconDenis B Rosemberg

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