PMID: 2110635Mar 26, 1990Paper

MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain

Neuroscience Letters
M Dragunow, R L Faull

Abstract

MK-801, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK-801 is dose-and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0 mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK-801 is unclear; however, the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site.

References

Nov 23, 1987·Neuroscience Letters·M Dragunow, H A Robertson
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D T MonaghanC W Cotman
Nov 1, 1988·Experimental Neurology·M DragunowG S Robertson
Jan 1, 1985·Molecular and Cellular Biology·T CurranI M Verma

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Citations

Mar 1, 1993·Brain Research. Molecular Brain Research·J DemmerW P Tate
Feb 5, 1993·Neuroscience Letters·P Hughes, M Dragunow
Jul 19, 1996·Neuroscience Letters·S FerréJ Serratosa
Jul 1, 1991·Brain Research Bulletin·D L McNeillR E Papka
Jan 1, 1995·Epilepsy Research·C D ApplegateD T Piekut
Mar 12, 1992·European Journal of Pharmacology·P F MorganM Linnoila
Aug 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N DahmenC Hiemke
Mar 3, 2004·Journal of the American College of Surgeons·Davida A RobinsonKenneth G Warner
Dec 12, 1996·European Journal of Pharmacology·J PutzkeW Zieglgänsberger
Apr 14, 2000·Brain Research. Molecular Brain Research·A HausmannC Humpel
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong Min AhnYong Sik Kim
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·J LiuF R Sharp

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