Abstract
Administration of the selective and full dopamine D1 receptor agonist SKF-82958 ((+/-)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-b enzazepine) (1 and 3 mg/kg i.p.) led to a dose-dependent induction of Fos protein in the rat striatum. The 3 mg/kg SKF-82958-induced expression of striatal Fos protein was blocked by the dopamine D1 receptor antagonist SCH-23390 (R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza zepine) (0.3 mg/kg i.p.). The noncompetitive NMDA receptor antagonist MK-801 ((5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5 ,10-imine) (1 mg/kg i.p.) also completely prevented striatal Fos induction by an injection of 3 mg/kg SKF-82958. These results suggest that dopamine D1 receptor activation by the full agonist SKF-82958 is sufficient to trigger Fos expression in the striatum, but that concomitant stimulation of NMDA receptors is required for the striatal Fos induction in response to dopamine D1 receptor activation.
References
May 1, 1992·Journal of Neurochemistry·K HisanagaF R Sharp
Jul 1, 1992·Neuroscience·G S RobertsonH C Fibiger
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S T YoungM J Iadarola
Aug 1, 1991·Experimental Neurology·A M Snyder-Keller
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson
Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Apr 1, 1989·Neuropharmacology·K M O'BoyleJ L Waddington
Nov 1, 1986·Journal of Neurochemistry·A M Young, H F Bradford
Jan 1, 1981·Neuroscience·F FonnumI Divac
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
May 1, 1995·Neuroscience·M L PaulH A Robertson
Apr 1, 1994·Brain Research. Molecular Brain Research·H Kiba, A Jayaraman
Jan 1, 1994·Brain Research Bulletin·D Wirtshafter, K E Asin
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·J LiuF R Sharp
Aug 1, 1993·The European Journal of Neuroscience·M A Cenci, A Björklund
Jan 1, 1993·Brain Research Bulletin·G Torres, C Rivier
Jun 1, 1996·Neuroscience·J Q Wang, J F McGinty
Citations
Nov 5, 2003·Brain Research Bulletin·David Wirtshafter, Amy C Sheppard
Jan 5, 2000·European Journal of Pharmacology·H M VasiliadisK M Dewar
May 9, 2002·Behavioural Brain Research·Glenn E Hunt, Iain S McGregor
Aug 23, 2002·Brain Research. Molecular Brain Research·Boris S SpektorRuth Luthi-Carter
Feb 25, 2000·Brain Research. Molecular Brain Research·J RadulovicJ Spiess
Mar 29, 2001·Neuroscience·S GiorgiS Consolo
Dec 3, 1999·The European Journal of Neuroscience·S FerréK Fuxe
Feb 2, 2010·Brain Research·Vesna PesićSabera Ruzdijić
Nov 18, 2005·Neuroscience·B M CampbellP D Walker
Apr 20, 2004·The European Journal of Neuroscience·Jean-Marc TaymansXavier Langlois
Jan 5, 2002·Journal of Biological Rhythms·L P Shearman, D R Weaver
May 20, 2004·Synapse·Christian W Kreipke, Paul D Walker
Apr 27, 2002·Journal of Neurophysiology·Long Chen, Charles R Yang