MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner.

The Journal of Biological Chemistry
D ZechnerC C Glembotski

Abstract

In cardiac myocytes the stimulation of p38 mitogen-activated protein kinase activates a hypertrophic growth program and the induction of the cardiac-specific genes associated with this program. This study focused on determining whether these novel growth-promoting effects are accompanied by the p38-mediated inhibition of apoptosis, and if so, what signaling pathways might be responsible. Primary neonatal rat ventricular myocytes were driven into apoptosis by treatments known to induce apoptosis in other cell types, e.g. incubation with anisomycin or overexpression constitutively active MEKK-1 (MEKK-1COOH), a protein that strongly activates extracellular signal-regulated kinase and N-terminal c-Jun kinase, but not p38. Overexpression of constitutively active MKK6, MKK6 (Glu), which selectively activates p38 in cardiac myocytes, protected cells from either anisomycin- or MEKK-1COOH-induced apoptosis. This protection was blocked by SB 203580, a selective p38 inhibitor. MKK6 (Glu) also activated transcription mediated by NF-kappaB, a factor which protects other cell types from apoptosis. The activation of NF-kappaB and the protection from apoptosis mediated by MKK6 (Glu) were both blocked by SB 203580. Interestingly, overexpression...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Aug 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·R Krstić, T Pexieder
Nov 16, 1995·Nature·P G Clarke, S Clarke
Nov 24, 1995·Science·Z XiaM E Greenberg
Dec 1, 1995·The Journal of Biological Chemistry·J M EnglishM H Cobb
Nov 1, 1995·The Journal of Clinical Investigation·W ChengP Anversa
Nov 1, 1994·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·P R Walker, M Sikorska
Aug 1, 1993·The Journal of Cell Biology·A Batistatou, L A Greene
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·T YamazakiY Yazaki
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Jan 1, 1993·Transactions of the American Clinical and Climatological Association·T N James
Mar 1, 1993·Immunology Today·J J Cohen
Feb 9, 1996·The Journal of Biological Chemistry·J HanR J Ulevitch
Feb 25, 1996·Experimental Cell Research·A Samali, T G Cotter
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·S XuM H Cobb
Jun 15, 1996·The Journal of Clinical Investigation·E TeigerP Hamet
Jan 1, 1996·Journal of Molecular and Cellular Cardiology·K TakedaT Kasajima
May 1, 1996·Current Biology : CB·A M Chinnaiyan, V M Dixit
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Jul 1, 1996·Molecular and Cellular Biochemistry·H S SharmaI Löw-Friedrich
Dec 1, 1996·Journal of Molecular and Cellular Cardiology·D V CummingD M Yellon

❮ Previous
Next ❯

Citations

Aug 14, 2001·Journal of Cellular Biochemistry·Y L GuoJ R Williamson
Nov 30, 2000·Biochemical and Biophysical Research Communications·B Törocsik, J Szeberényi
Oct 3, 2000·Journal of Molecular and Cellular Cardiology·H LüssG Heusch
Jul 11, 2001·Journal of Molecular and Cellular Cardiology·M W BergmannR von Harsdorf
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Yoshiharu HiguchiMasatsugu Hori
Feb 15, 2001·Bulletin of Experimental Biology and Medicine·L M NepomnyashchikhD E Semenov
Aug 9, 2012·Archives of Dermatological Research·Lei YaoShan-Shan Li
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·T KurosuO Miura
Sep 29, 2009·Apoptosis : an International Journal on Programmed Cell Death·Olga A AkimovaSergei N Orlov
Dec 30, 2008·Biochemical Pharmacology·Antonella MuscellaSanto Marsigliante
Apr 6, 2000·The American Journal of Cardiology·A Clerk, P H Sugden
Aug 2, 2002·Cryobiology·Jonathan R RobertsAndrew G Demaine
Nov 30, 1999·Thrombosis Research·C Pampolina, A McNicol
Oct 31, 2003·Experimental Hematology·Betty S PaceStuart D Critz
Mar 30, 2002·Journal of the American College of Cardiology·Naoya MaekawaMitsuru Seishima
Aug 5, 2000·Free Radical Biology & Medicine·Y M Janssen-HeiningerP A Baeuerle
Jun 6, 2000·Trends in Biochemical Sciences·A R Nebreda, A Porras
Jan 11, 2001·Trends in Cardiovascular Medicine·J Han, J D Molkentin
Mar 7, 2002·The Biochemical Journal·Christopher J DoughertyKeith A Webster
Feb 19, 2004·The Journal of Experimental Medicine·Maria Alvarado-KristenssonTommy Andersson
May 15, 2002·Antioxidants & Redox Signaling·Miguel P SoaresFritz H Bach
Sep 22, 2006·Antioxidants & Redox Signaling·Kazuhiko Nishida, Kinya Otsu
Jun 16, 2001·Molecular Biology of the Cell·R G DeschesnesJ Landry
Nov 18, 2003·Molecular Biology of the Cell·Almudena PorrasAngel R Nebreda
May 12, 2000·Critical Care Medicine·T ObataM B Yaffe
Jan 10, 2002·Critical Care Medicine·Saman Arbabi, Ronald V Maier
Feb 2, 2000·Current Opinion in Nephrology and Hypertension·A J Ingram, J W Scholey
Apr 15, 2009·Molecular and Cellular Biology·Vladislava JuricLester F Lau
Mar 2, 2006·Molecular and Cellular Biology·Nicholas FarleyMercedes Rincón
Jun 8, 2006·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·I V Shemarova, V P Nesterov
Feb 11, 2000·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·S O KimM V Cohen
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·R WhittakerC C Glembotski
Feb 28, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Isaac SamuelAsgar Zaheer
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jun-Jie LiHui-Hua Li
Dec 10, 1999·The Journal of Clinical Investigation·F Liang, D G Gardner

❮ Previous
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