MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis

Journal of Cell Science
Xian ChengLi Zhang

Abstract

Papillary thyroid cancer (PTC), the most common thyroid malignancy, has a strong propensity for cervical lymph node metastasis (LNM), which increases the risk of locoregional recurrence and decreases survival probability in some high-risk groups. Hence, there is a pressing requirement for a reliable biomarker to predict LNM in thyroid cancer. In the present study, MKL1 (also known as MRTFA) expression was significantly increased in PTC patients with LNM compared with those without. Further receiver operating characteristic (ROC) analysis showed that MKL1 expression had a diagnostic value in the differentiation of LNM in PTC. Furthermore, Kaplan-Meier analysis revealed that high MKL1 expression was associated with significantly decreased survival in PTC. Additionally, our study indicated that MKL1 promoted the migration and invasion of PTC cells. MKL1 interacted with and recruited Smad3 to the promoter of MMP2 to activate MMP2 transcription upon treatment with TGF-β. Moreover, there was significant correlation between expression of TGF-β, MKL1 and MMP2 in our clinical cohort of specimens from individuals with PTC. Our results suggest that the detection of MKL1 expression could be used to predict cervical LNM and inform post-oper...Continue Reading

References

Apr 24, 2010·Nature Reviews. Molecular Cell Biology·Eric N Olson, Alfred Nordheim
Jun 20, 2012·FEBS Letters·Carl-Henrik HeldinAristidis Moustakas
Jul 16, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mingzhao XingJustin Bishop
May 9, 2015·International Journal of Oncology·Wen-Long ZhangJian-Hua Zhang
Aug 5, 2015·Biochimica Et Biophysica Acta·Zhiwen FanYong Xu
Aug 27, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Xiabin LanTing Zhang
Oct 18, 2015·Biochemical and Biophysical Research Communications·Hongpeng HeTong-Cun Zhang
Nov 28, 2015·Surgical Oncology Clinics of North America·Cord SturgeonDina Elaraj
Dec 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Youzhi ZhuXiangjin Chen
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Nurul-Syakima Ab MutalibRahman Jamal
Nov 23, 2016·Endocrine-related Cancer·Xiaopei ShenMingzhao Xing
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Miguel MeloPaula Soares
Apr 1, 2017·JAMA : the Journal of the American Medical Association·Hyeyeun LimCari M Kitahara
May 30, 2017·Molecular and Cellular Endocrinology·Thanyawat SasanakietkulTobias Carling
Jul 1, 2017·Progress in Molecular Biology and Translational Science·Amanda Y Hendrix, Farrah Kheradmand
Jul 18, 2017·Molecular and Cellular Endocrinology·Sylvia L Asa, Shereen Ezzat
Jul 22, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthew T MenendezCourtney T Griffin
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Aug 19, 2017·Scientific Reports·Lakisha D Moore-SmithSelvarangan Ponnazhagan
Jan 18, 2018·International Journal of Surgery·Kyle R JosephGuy D Eslick

❮ Previous
Next ❯

Citations

Feb 29, 2020·Cancer Management and Research·Jin-Xing GongQing-Hai Ji
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Baoyu ChenYong Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.