MMP-11 as a biomarker for metastatic breast cancer by immunohistochemical-assisted imaging mass spectrometry

Analytical and Bioanalytical Chemistry
Raquel González de VegaAlfredo Sanz-Medel

Abstract

MMP-11 is a member of the matrix metalloproteinase family (MMPs) which are overexpressed in cancer cells, stromal cells and the adjacent microenvironment. The MMP protein family encompasses zinc-dependent endopeptidases that degrade the extracellular matrix (ECM), facilitating the breakdown of the basal membrane and matrix connective tissues. This function is believed to be important in cancer development and metastasis. This paper investigated a gold nanoparticle-based immunohistochemical assay to visualise the distribution of MMP-11 in human breast cancer tissues from eight patients with and without metastases by employing laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The expression of MMP-11 was increased and more heterogeneous in metastatic specimens compared to non-metastatic tumour samples. These findings demonstrate that imaging breast tumours by LA-ICP-MS may be a useful tool to aid the prognosis and treatment of breast cancer. As an example, samples of two patients are presented who were diagnosed with matching characteristics and grades of breast cancer. Although both patients had a similar prognosis and treatment, only one developed metastases.

References

May 30, 2002·Analytical Chemistry·Vladimir I BaranovScott D Tanner
Mar 8, 2007·British Journal of Cancer·F J VizosoJ L García-Muñiz
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Roy M BremnesLill-Tove Busund
May 1, 2012·Analytical and Bioanalytical Chemistry·Ioana KonzAlfredo Sanz-Medel
Feb 26, 2014·Journal of Translational Medicine·Giuseppe RoscilliLuigi Aurisicchio
Feb 20, 2016·International Journal of Oncology·Xu ZhangYupei Zhao
Aug 13, 2017·Analytical and Bioanalytical Chemistry·Raquel González de VegaAlfredo Sanz Medel
Mar 3, 2018·Cellular Oncology (Dordrecht)·Noemi EiroFrancisco J Vizoso

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Citations

Feb 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcela VlcnovskaMarketa Vaculovicova
May 5, 2021·The Journal of International Medical Research·Xiwen HuangXunwei Deng
May 22, 2021·Chemical Reviews·Philip A DobleDavid Clases
Oct 24, 2019·Analytical Chemistry·Mika T WesterhausenPhilip A Doble

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