MMP-9 and CD68(+) cells are required for tissue remodeling in response to natural hydroxyapatite.

Journal of Molecular Histology
Willian F ZambuzziJosé M Granjeiro

Abstract

Large bone defects represent major clinical problems in the practice of reconstructive orthopedic and craniofacial surgery. The aim of this study was to examine, through immunohistochemistry approach, the involvement of MMP-9 and CD68(+) cells during tissue remodeling in response to natural hydroxyapatite (HA) implanted in rat subcutaneous tissue. Before experimentation, forty animals were randomly distributed into two experimental groups: Group-I (Gen-Ox micro-granules) and Group-II (Gen-Ox macro-granules). Afterwards, the biopsies were collected after 10, 20, 30, and 60 days post-implantation. Our results showed that at 10 days, a low-renewal foreign body type granuloma formation was observed in most of the cases. Macrophage- and fibroblast-like cells were the predominant type of cells positively stained for MMP-9 in both groups. Once macrophage-like cells seemed to be the major source of MMP9, antibody against pan-CD68 epitope was used to correlate these findings. In agreement, MMP-9 and CD68(+) cells were distributed at the periphery and the central region of the granuloma in all experimental periods, however no staining was observed in cell contacting to material. Besides macrophages, the lysosomal glycoprotein epitope rec...Continue Reading

References

Apr 29, 1998·Current Opinion in Oncology·R Elenitsas, L M Schuchter
May 13, 1999·Lancet·A Van Heest, M Swiontkowski
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M DelaisséN T Foged
Sep 7, 2001·Current Opinion in Cell Biology·L J McCawley, L M Matrisian
Dec 6, 2001·Annals of Clinical Biochemistry·S D Vasikaran
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
Aug 24, 2004·Brazilian Dental Journal·Rodrigo Cardoso de OliveiraJosé Mauro Granjeiro
May 12, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B RittenbergH C Tenenbaum
Oct 4, 2005·Journal of Molecular Histology·Thais Accorsi-MendonçaJosé Mauro Granjeiro
Mar 28, 2006·Journal of Cellular and Molecular Medicine·U KneserR E Horch
Aug 22, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Renato MenezesJosé Mauro Granjeiro
Oct 20, 2006·Journal of Lower Genital Tract Disease·Audrey P GarrettEllen E Sheets
Jan 31, 2007·Brazilian Dental Journal·Willian Fernando ZambuzziJosé Mauro Granjeiro
Mar 14, 2007·Acta Odontologica Scandinavica·Angélica R HannasLeo Tjäderhane
Nov 8, 2007·Journal of Molecular Histology·Thais Accorsi-MendonçaJosé Mauro Granjeiro
Jan 29, 2008·Recent Patents on Cardiovascular Drug Discovery·György DormánPéter Ferdinandy
Apr 22, 2008·Brazilian Oral Research·Thais Accorsi-MendonçaJosé Mauro Granjeiro
Nov 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paulo G CoelhoJack E Lemons
Nov 8, 2008·Molecular and Cellular Biochemistry·Willian F ZambuzziCarmen V Ferreira
Jun 6, 2009·Archives of Oral Biology·Mauro V CorottiJosé M Granjeiro
Jun 13, 2009·Current Pharmaceutical Design·Andrew KeibelMahesh C Sharma
Oct 20, 2009·Journal of Molecular Histology·Katiucia Batista Silva PaivaJosé Mauro Granjeiro
Dec 1, 2005·Journal of Applied Oral Science : Revista FOB·Willian Fernando ZambuzziJosé Mauro Granjeiro

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Citations

May 17, 2011·PloS One·Virginia Llopis-HernándezManuel Salmerón-Sánchez
Mar 23, 2011·Journal of Materials Science. Materials in Medicine·Thais Accorsi-MendonçaJosé Mauro Granjeiro
Mar 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Laura N VandenbergMichael Levin
Aug 27, 2014·Archives of Biochemistry and Biophysics·Katiucia Batista Silva Paiva, José Mauro Granjeiro
Jun 24, 2017·Journal of Biomedical Materials Research. Part a·M C RossiW F Zambuzzi
Oct 2, 2013·BioResearch Open Access·Virginia Llopis-HernándezManuel Salmerón-Sánchez
Jan 10, 2012·Clinical Oral Implants Research·Igor Iuco Castro-SilvaJosé Mauro Granjeiro
Oct 3, 2014·Annals of Thoracic Medicine·Abdullah A Alangari
Sep 12, 2019·Journal of Applied Oral Science : Revista FOB·Cintia Kazuko TokuharaRodrigo Cardoso de Oliveira
Feb 13, 2019·Annals of Thoracic Medicine·Mohamed S Al-MoamaryMohamed S Al-Hajjaj
Mar 18, 2020·Cell Biology International·Nayara F C CastroPatrícia S L Vilamaior
Mar 24, 2011·Clinical Oral Implants Research·Willian Fernando ZambuzziJosé Mauro Granjeiro
Feb 26, 2011·Biotechnology and Bioengineering·Willian F ZambuzziJosé M Granjeiro
Nov 8, 2020·Journal of Materials Science. Materials in Medicine·Carolina Simão AlbanoPaulo Noronha Lisboa-Filho
Jul 28, 2020·Heliyon·Carolina Simão AlbanoPaulo Noronha Lisboa-Filho
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Célio Junior da Costa FernandesWillian Fernando Zambuzzi

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