MMP-9 expression in meningiomas: a prognostic marker for recurrence risk?

Journal of Neuro-oncology
V BarresiG Barresi

Abstract

Despite total macroscopic resection of meningiomas relapses do occur in these tumours, possibly because of microscopic clusters of neoplastic cells left in the dura mater or in the arachnoid membrane. The invasiveness of the neoplastic cells of human meningiomas has been related to expression of matrix-metalloproteinase-9 (MMP-9), a peptidase actively implicated in the degradation of the extracellular matrix; nonetheless, the prognostic value of MMP-9 in the risk of recurrence of meningiomas has not been sufficiently investigated. Herein, we analysed MMP-9 expression in a series of meningiomas of different histotype and histological grade and assessed its correlation with various clinico-pathological indicators and with the clinical outcome of these tumours. We also tested the eventual pro-angiogenic role of MMP-9 expression in meningiomas through its correlation with vascular endothelial growth factor (VEGF) and microvessel density (MVD) revealed in the same cases. MMP-9 expression was observed in 64% of cases; high expression of this protein was significantly associated with high histological grade and proliferation index, but not with high MVD, of the tumours. A trend towards correlation between MMP-9 and VEGF expression was...Continue Reading

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Citations

Mar 17, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Eiji IwadoIsao Date
Jan 21, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Valeria BarresiGiovanni Tuccari
Feb 4, 2011·Brain Tumor Pathology·Valeria Barresi
Oct 15, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Valeria Barresi, Giovanni Tuccari
Oct 26, 2016·International Journal of Oncology·Harcharan K RoopraiGeoffrey J Pilkington
Dec 15, 2012·Acta neurochirurgica·Fateme SalehiGelareh Zadeh
Aug 4, 2015·Neurosurgical Focus·Michael KarsyMark A Mahan
Sep 7, 2017·Journal of Veterinary Internal Medicine·M T MandaraG Guelfi
Mar 19, 2013·Journal of Neuro-oncology·Valeria BarresiGiovanni Tuccari
Dec 3, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Florian SimonStefan Rieken

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