MMP-9 in serum correlates with the development of pulmonary complications in experimental acute pancreatitis

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
T KeckU T Hopt

Abstract

The prediction of the course of acute pancreatitis and its arising complications is of clinical importance. The aim of this study was to judge the time course and relevance of matrix metalloproteinase-9 (MMP-9), a PMN-derived protease, for the development of pulmonary complications in two models of acute pancreatitis. MMP-9 was evaluated in a standardized experimental model of acute pancreatitis. Mild edematous (n = 12) and severe necrotizing pancreatitis (n = 48) were induced by intravenous cerulein or intravenous cerulein and intraductal application of glycodeoxycholic acid and compared to control animals. 1, 6, 9, 12, 24 and 72 h after induction, rats were sacrificed and damage to the lung and the pancreas was quantified by histology and extravasation of Evans blue. At 1, 6, 9, 12, 24 and 72 h, we determined MMP-9 in serum by ELISA. In our model, MMP-9 in serum was increased in the group with severe acute pancreatitis in comparison to mild edematous pancreatitis and controls at each evaluated time point (p < 0.05). The maximum release of MMP-9 preceded the development of pulmonary complications, verified by histology and extravasation of Evans blue. MMP-9 showed a negative predictive value of 96.2% and a positive predictive ...Continue Reading

References

Mar 1, 1978·Chest·A De TroyerM Englert
Feb 1, 1977·The Journal of Surgical Research·J H Ranson, B S Pasternack
Jan 1, 1992·Annals of Surgery·J SchmidtA L Warshaw
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Dec 1, 1984·Gut·S L BlameyD C Carter
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·J L FrossardC M Pastor
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jens WernerMarkus W Büchler
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Tobias KeckErnst Klar
Mar 3, 2004·Digestive Diseases and Sciences·Eftihia PolyzogopoulouCharalambos A Gogos
Nov 6, 2004·Gastroenterology Clinics of North America·Georgios I Papachristou, David C Whitcomb
Apr 28, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Tobias KeckCarlos Fernández-del-Castillo

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Citations

May 16, 2009·Critical Care : the Official Journal of the Critical Care Forum·Eduardo Ferat-OsorioArmando Isibasi
Apr 16, 2014·PloS One·Fumiaki ShikataHironori Izutani
Feb 25, 2010·The American Journal of Gastroenterology·Subhankar ChakrabortySurinder K Batra
May 2, 2012·Journal of Leukocyte Biology·Thomas F Tracy

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