MMP-9 microsatellite polymorphism and multiple sclerosis

Journal of Neuroimmunology
Nicola FiottiMarino Zorzon

Abstract

A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P<0.0001) and prevalence of carriers of > or =22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95% CI: 1.7-6.8, P<0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33+/-10 vs. 28+/-10, P=0.027). No differences were found in the main MRI parameters.

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Citations

May 26, 2005·Journal of Neuroimmunology·Robert GoertschesXavier Montalban
Jun 17, 2005·Journal of Neuroimmunology·Fabrizio GiulianiV Wee Yong
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yimin WangJianhui Zhang
Jan 10, 2012·Progress in Histochemistry and Cytochemistry·Ferdinando Mannello, Virginia Medda
Oct 7, 2008·Journal of Neuroimmunology·Yvonne BenesováJosef Bednarík
Mar 27, 2007·Journal of the Neurological Sciences·V Wee YongLuanne M Metz
Jul 28, 2009·Biochimica Et Biophysica Acta·Miriam Fanjul-FernándezCarlos López-Otín
Nov 1, 2016·Journal of Neurochemistry·Behnam VafadariLeszek Kaczmarek
Apr 19, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nicola FiottiGiuseppe Ravalico
Nov 17, 2005·Nature Reviews. Neuroscience·V Wee Yong
Sep 18, 2007·Expert Review of Neurotherapeutics·Masaaki NiinoHidenao Sasaki
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·A Karim KaderXifeng Wu
Dec 21, 2006·Cancer Research·A Karim KaderXifeng Wu

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