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MMP-Activated Fluorescence Imaging Detects Early Joint Inflammation in Collagen-Antibody-Induced Arthritis in CC-Chemokine Receptor-2-Null Mice, In-Vivo

International Journal of Inflammation

Jul 15, 2011

Jessica M IbarraSeema S Ahuja

Abstract

The Standard measures of experimental arthritis fail to detect, visualize, and quantify early inflammation and disease activity. Here, we describe the use of an injectable MMP-activated fluorescence agent for in vivo quantification of acute inflammation produced by collagen-antibody-ind...read more

Mentioned in this Paper

Histology Procedure
CCR2 gene
Ankle Joint Structure
Arthritis, Experimental
Synovial Cyst
C-C Chemokine Receptor Type 2
Diamond-Blackfan Anemia 1
Fluorescent stain
Histology
Chemokine receptor
Paper Details
References
  • References9
  • Citations4
1

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Chemokines & Chemokine Receptors

Chemokines are a subset of cytokines which induce chemotaxis in cells expressing chemokine receptors. Chemokines can be broadly categorized into two functional subgroups, homeostatic (basal expression in lymphoid tissues for surveillance purposes) or inflammatory (released during injury to recruit immune effector cells). Chemokine receptors are G-protein coupled receptors which, upon chemokine binding, induce calcium influx into the cell. Find the latest research on chemokines and chemokine receptors here.

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MMP-Activated Fluorescence Imaging Detects Early Joint Inflammation in Collagen-Antibody-Induced Arthritis in CC-Chemokine Receptor-2-Null Mice, In-Vivo

International Journal of Inflammation

Jul 15, 2011

Jessica M IbarraSeema S Ahuja

PMID: 21755029

DOI: 10.4061/2011/691587

Abstract

The Standard measures of experimental arthritis fail to detect, visualize, and quantify early inflammation and disease activity. Here, we describe the use of an injectable MMP-activated fluorescence agent for in vivo quantification of acute inflammation produced by collagen-antibody-ind...read more

Mentioned in this Paper

Histology Procedure
CCR2 gene
Ankle Joint Structure
Arthritis, Experimental
Synovial Cyst
C-C Chemokine Receptor Type 2
Diamond-Blackfan Anemia 1
Fluorescent stain
Histology
Chemokine receptor

Feeds With Similar Papers

Chemokines & Chemokine Receptors

Chemokines are a subset of cytokines which induce chemotaxis in cells expressing chemokine receptors. Chemokines can be broadly categorized into two functional subgroups, homeostatic (basal expression in lymphoid tissues for surveillance purposes) or inflammatory (released during injury to recruit immune effector cells). Chemokine receptors are G-protein coupled receptors which, upon chemokine binding, induce calcium influx into the cell. Find the latest research on chemokines and chemokine receptors here.

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Paper Details
References
  • References9
  • Citations4
1

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